Cargando…

Substituted 2-[(2-Oxo-2H-[1,2,4]triazino [2,3-c]quinazolin-6-yl)thio]acetamides with Thiazole and Thiadiazole Fragments: Synthesis, Physicochemical Properties, Cytotoxicity, and Anticancer Activity

The series of novel N-R-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamides with thiazole and thiadiazole fragments in a molecule were obtained by alkylation of potassium salts 1.1–1.4 by N-hetaryl-2-chloroacetamides and by aminolysis of activated acids 2.1–2.4 with N,N’-carbonyld...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kovalenko, Sergey I., Nosulenko, Inna S., Voskoboynik, Alexey Yu., Berest, Galina G., Antypenko, Lyudmyla N., Antypenko, Alexey N., Katsev, Andrey M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Österreichische Apotheker-Verlagsgesellschaft 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528059/ https://www.ncbi.nlm.nih.gov/pubmed/23264935 http://dx.doi.org/10.3797/scipharm.1208-07

Ejemplares similares

Synthesis of New 6-{[ω-(Dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones and Evaluation of their Anticancer and Antimicrobial Activities
por: Berest, Galina G., et al.
Publicado: (2012)

Synthesis and Antimicrobial Activity of 6-Thioxo-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]-quinazolin-2-one Derivatives
por: Nosulenko, Inna S., et al.
Publicado: (2014)

Directed Search of Anti-inflammatory Agents Among (3H-Quinazoline-4-ylidene)hydrazides of N-protected Amino acids and their Heterocyclization Products
por: Martynenko, Yulya, et al.
Publicado: (2020)

Design and Evaluation of Novel Antimicrobial and Anticancer Agents Among Tetrazolo[1,5-c]quinazoline-5-thione S-Derivatives
por: Antypenko, Lyudmyla M., et al.
Publicado: (2013)

Synthesis and Anticancer Activity of 2-(Alkyl-, Alkaryl-, Aryl-, Hetaryl-)-[1,2,4]triazolo[1,5-c]quinazolines
por: Kovalenko, Sergiy I., et al.
Publicado: (2013)

Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs
por: Voskoboynik, Oleksii Yu., et al.
Publicado: (2017)

Search for Compounds with Hypoglycemic Activity in the Series of 1-[2-(1H-Tetrazol-5-yl)-R(1)-phenyl]-3-R(2)-phenyl(ethyl)ureas and R(1)-Tetrazolo[1,5-c]quinazolin-5(6H)-ones
por: Antypenko, Oleksii M., et al.
Publicado: (2016)

Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase
por: Antypenko, Lyudmyla, et al.
Publicado: (2023)

Synthesis and Bronchodilator Studies of Some Novel 6-Alkyl/Aryl-1,2,4-Triazino[4,3-c]Quinazolines
por: Kombu, Rajan Subramanian, et al.
Publicado: (2008)

N-(Thiazol-2-yl)acetamide
por: Yunus, Uzma, et al.
Publicado: (2008)

N-Cyclohexyl-2-oxo-2-phenylacetamide
por: Jia, Ze-Jun, et al.
Publicado: (2012)

2,2-Diphenyl-N-(1,3-thiazol-2-yl)acetamide
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

2-(2-Chlorophenyl)-2-oxo-N-phenylacetamide
por: Dai, Jing, et al.
Publicado: (2011)

Synthesis of Some Novel Fused Pyrimido[4″,5″:5′,6′]-[1,2,4]triazino[3′,4′:3,4] [1,2,4]triazino[5,6-b]indoles with Expected Anticancer Activity
por: Ali, Rania S., et al.
Publicado: (2018)

2-Methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazolin-8-yl thiophene-2-carboxylate
por: El-Azab, Adel S., et al.
Publicado: (2012)

2-(2-Fluorophenyl)-N-(1,3-thiazol-2-yl)acetamide
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

2-(2-Methylphenyl)-N-(1,3-thiazol-2-yl)acetamide
por: Narayana, B., et al.
Publicado: (2014)

2-(Naphthalen-1-yl)-N-(1,3-thiazol-2-yl)acetamide
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

2-[5-(Benzo[d]thiazol-2-yl)thiophen-2-yl]benzo[d]thiazole
por: Potgieter, Kim, et al.
Publicado: (2010)

2-(2,6-Dichlorophenyl)-N-(1,3-thiazol-2-yl)acetamide
por: Nayak, Prakash S., et al.
Publicado: (2013)

2-(4-Chlorophenyl)-N-(1,3-thiazol-2-yl)acetamide
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

Crystal structure of N-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)-2-(thiophen-3-yl)acetamide
por: Vu Quoc, Trung, et al.
Publicado: (2017)

2-(Benzo[d]thiazol-2-ylsulfanyl)-N-(6-methyl-2-pyridyl)acetamide
por: Zhao, Bing, et al.
Publicado: (2009)

N-(1,3-Thiazol-2-yl)-2-(2,4,6-trimethylphenyl)acetamide
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

2-(2,4-Dichlorophenyl)-N-(1,3-thiazol-2-yl)acetamide
por: Nayak, Prakash S., et al.
Publicado: (2013)

N-(5-Methylsulfanyl-1,3,4-thiadiazol-2-yl)acetamide
por: Zhang, Guo-Ying
Publicado: (2009)

2,2,2-Trifluoro-N-(4-methyl-2-oxo-2H-chromen-7-yl)acetamide
por: Li, Hong-Da, et al.
Publicado: (2012)

Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis
por: Yang, Zheng, et al.
Publicado: (2016)

2-Oxo-2-(2-oxo-2H-chromen-3-yl)ethyl pyrrolidine-1-carbodithioate
por: Kumar, K. Mahesh, et al.
Publicado: (2013)

2-(3,4-Dichlorophenyl)-N-(1,3-thiazol-2-yl)acetamide
por: Nayak, Prakash S., et al.
Publicado: (2013)

(Z)-N-[2-(Dimethylammonio)ethyl]thioacetamide chloride
por: Dutkiewicz, Grzegorz, et al.
Publicado: (2007)

5-(Thiophen-2-ylmethyl)-1,3,4-thiadiazol-2-amine
por: Köysal, Yavuz, et al.
Publicado: (2012)

N-(5-Benzylsulfanyl-1,3,4-thiadiazol-2-yl)-2-(piperidin-1-yl)acetamide
por: Ismailova, D. S., et al.
Publicado: (2014)

N-[(3-Ethylphenyl)carbamothioyl]-2,2-diphenylacetamide
por: Yusof, Mohd Sukeri Mohd, et al.
Publicado: (2013)

N-(4-Methoxy-2-nitrophenyl)-2-(3-methyl-2-oxo-1,2-dihydroquinoxalin-1-yl)acetamide
por: Missioui, Mohcine, et al.
Publicado: (2023)

Synthesis of Novel Pyrido[4,3-e][1,2,4]triazino[3,2-c][1,2,4]thiadiazine 6,6-dioxide Derivatives with Potential Anticancer Activity
por: Sławiński, Jarosław, et al.
Publicado: (2015)

2-Amino-N-[3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl]acetamide
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

2,2-Diphenyl-N-{[2-(trifluoromethyl)phenyl]carbamothioyl}acetamide
por: Yusof, Mohd Sukeri Mohd, et al.
Publicado: (2013)

N-[(2,6-Diethylphenyl)carbamothioyl]-2,2-diphenylacetamide
por: Yusof, Mohd Sukeri Mohd, et al.
Publicado: (2013)

N-(1,3-Thiazol-2-yl)-N′-[(thiophen-2-yl)carbonyl]thiourea hemihydrate
por: Singh, Durga Prasad, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1l1nsc3094tg85obvbdlru159r