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Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines

This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody t...

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Detalles Bibliográficos
Autores principales: Li, Li-Jie, Li, Ming-Yi, Li, Yan-Tuan, Feng, Jing-Jing, Hao, Feng-Qiang, Zhang, Lun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528116/
https://www.ncbi.nlm.nih.gov/pubmed/23342387
http://dx.doi.org/10.3390/md10122648
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author Li, Li-Jie
Li, Ming-Yi
Li, Yan-Tuan
Feng, Jing-Jing
Hao, Feng-Qiang
Zhang, Lun
author_facet Li, Li-Jie
Li, Ming-Yi
Li, Yan-Tuan
Feng, Jing-Jing
Hao, Feng-Qiang
Zhang, Lun
author_sort Li, Li-Jie
collection PubMed
description This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis.
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spelling pubmed-35281162012-12-28 Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines Li, Li-Jie Li, Ming-Yi Li, Yan-Tuan Feng, Jing-Jing Hao, Feng-Qiang Zhang, Lun Mar Drugs Article This study evaluates the effects of Sargassum pallidum polysaccharides (SPP) on the immune responses in a chicken model. The adjuvanticity of Sargassum pallidum polysaccharides in Newcastle disease (ND), infectious bronchitis (IB) and avian influenza (AI) was investigated by examining the antibody titers and lymphocyte proliferation following immunization in chickens. The chickens were administrated combined ND, IB and AI inactivated vaccines containing SPP at 10, 30 and 50 mg/mL, using an oil adjuvant vaccine as a control. The ND, IB and AI antibody titers and the lymphocyte proliferation were enhanced at 30 mg/mL SPP. In conclusion, an appropriate dose of SPP may be a safe and efficacious immune stimulator candidate that is suitable for vaccines to produce early and persistent prophylaxis. MDPI 2012-11-22 /pmc/articles/PMC3528116/ /pubmed/23342387 http://dx.doi.org/10.3390/md10122648 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Li-Jie
Li, Ming-Yi
Li, Yan-Tuan
Feng, Jing-Jing
Hao, Feng-Qiang
Zhang, Lun
Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines
title Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines
title_full Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines
title_fullStr Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines
title_full_unstemmed Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines
title_short Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines
title_sort adjuvant activity of sargassum pallidum polysaccharides against combined newcastle disease, infectious bronchitis and avian influenza inactivated vaccines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528116/
https://www.ncbi.nlm.nih.gov/pubmed/23342387
http://dx.doi.org/10.3390/md10122648
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