Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.

Five new diterpenoids 1–5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cy...

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Autores principales: Roy, Prodip K., Maarisit, Wilmar, Roy, Michael C., Taira, Junsei, Ueda, Katsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528123/
https://www.ncbi.nlm.nih.gov/pubmed/23201595
http://dx.doi.org/10.3390/md10122741
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author Roy, Prodip K.
Maarisit, Wilmar
Roy, Michael C.
Taira, Junsei
Ueda, Katsuhiro
author_facet Roy, Prodip K.
Maarisit, Wilmar
Roy, Michael C.
Taira, Junsei
Ueda, Katsuhiro
author_sort Roy, Prodip K.
collection PubMed
description Five new diterpenoids 1–5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC(50) 5.85 μM), while these new diterpenoids 1–5 were much less active (IC(50) 28.2–91.4 μM).
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spelling pubmed-35281232012-12-28 Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp. Roy, Prodip K. Maarisit, Wilmar Roy, Michael C. Taira, Junsei Ueda, Katsuhiro Mar Drugs Article Five new diterpenoids 1–5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC(50) 5.85 μM), while these new diterpenoids 1–5 were much less active (IC(50) 28.2–91.4 μM). MDPI 2012-11-30 /pmc/articles/PMC3528123/ /pubmed/23201595 http://dx.doi.org/10.3390/md10122741 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Roy, Prodip K.
Maarisit, Wilmar
Roy, Michael C.
Taira, Junsei
Ueda, Katsuhiro
Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.
title Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.
title_full Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.
title_fullStr Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.
title_full_unstemmed Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.
title_short Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.
title_sort five new diterpenoids from an okinawan soft coral, cespitularia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528123/
https://www.ncbi.nlm.nih.gov/pubmed/23201595
http://dx.doi.org/10.3390/md10122741
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