Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation

Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, it is not clear whether EBV plays a role in the pathogenesis of these diseases, and if so, by whi...

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Detalles Bibliográficos
Autores principales: Lossius, Andreas, Johansen, Jorunn N., Torkildsen, Øivind, Vartdal, Frode, Holmøy, Trygve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528287/
https://www.ncbi.nlm.nih.gov/pubmed/23342374
http://dx.doi.org/10.3390/v4123701
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author Lossius, Andreas
Johansen, Jorunn N.
Torkildsen, Øivind
Vartdal, Frode
Holmøy, Trygve
author_facet Lossius, Andreas
Johansen, Jorunn N.
Torkildsen, Øivind
Vartdal, Frode
Holmøy, Trygve
author_sort Lossius, Andreas
collection PubMed
description Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, it is not clear whether EBV plays a role in the pathogenesis of these diseases, and if so, by which mechanisms the virus may contribute. In this review, we discuss possible viral and immunological mechanisms that might explain associations between EBV and autoimmune diseases and whether these associations represent causes or effects of inflammation and autoimmunity.
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spelling pubmed-35282872013-01-02 Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation Lossius, Andreas Johansen, Jorunn N. Torkildsen, Øivind Vartdal, Frode Holmøy, Trygve Viruses Review Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, it is not clear whether EBV plays a role in the pathogenesis of these diseases, and if so, by which mechanisms the virus may contribute. In this review, we discuss possible viral and immunological mechanisms that might explain associations between EBV and autoimmune diseases and whether these associations represent causes or effects of inflammation and autoimmunity. MDPI 2012-12-13 /pmc/articles/PMC3528287/ /pubmed/23342374 http://dx.doi.org/10.3390/v4123701 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Lossius, Andreas
Johansen, Jorunn N.
Torkildsen, Øivind
Vartdal, Frode
Holmøy, Trygve
Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation
title Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation
title_full Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation
title_fullStr Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation
title_full_unstemmed Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation
title_short Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation
title_sort epstein-barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528287/
https://www.ncbi.nlm.nih.gov/pubmed/23342374
http://dx.doi.org/10.3390/v4123701
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