Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers

Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hams...

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Autores principales: Wahl-Jensen, Victoria, Bollinger, Laura, Safronetz, David, de Kok-Mercado, Fabian, Scott, Dana P., Ebihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528289/
https://www.ncbi.nlm.nih.gov/pubmed/23242370
http://dx.doi.org/10.3390/v4123754
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author Wahl-Jensen, Victoria
Bollinger, Laura
Safronetz, David
de Kok-Mercado, Fabian
Scott, Dana P.
Ebihara, Hideki
author_facet Wahl-Jensen, Victoria
Bollinger, Laura
Safronetz, David
de Kok-Mercado, Fabian
Scott, Dana P.
Ebihara, Hideki
author_sort Wahl-Jensen, Victoria
collection PubMed
description Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models.
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spelling pubmed-35282892013-01-02 Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers Wahl-Jensen, Victoria Bollinger, Laura Safronetz, David de Kok-Mercado, Fabian Scott, Dana P. Ebihara, Hideki Viruses Review Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relevant pathology and coagulation parameters, are compared directly with the mouse, guinea pig and nonhuman primate models. MDPI 2012-12-14 /pmc/articles/PMC3528289/ /pubmed/23242370 http://dx.doi.org/10.3390/v4123754 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Wahl-Jensen, Victoria
Bollinger, Laura
Safronetz, David
de Kok-Mercado, Fabian
Scott, Dana P.
Ebihara, Hideki
Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers
title Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers
title_full Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers
title_fullStr Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers
title_full_unstemmed Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers
title_short Use of the Syrian Hamster as a New Model of Ebola Virus Disease and Other Viral Hemorrhagic Fevers
title_sort use of the syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528289/
https://www.ncbi.nlm.nih.gov/pubmed/23242370
http://dx.doi.org/10.3390/v4123754
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