Immune Responses to West Nile Virus Infection in the Central Nervous System

West Nile virus (WNV) continues to cause outbreaks of severe neuroinvasive disease in humans and other vertebrate animals in the United States, Europe, and other regions of the world. This review discusses our understanding of the interactions between virus and host that occur in the central nervous...

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Detalles Bibliográficos
Autores principales: Cho, Hyelim, Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528292/
https://www.ncbi.nlm.nih.gov/pubmed/23247502
http://dx.doi.org/10.3390/v4123812
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author Cho, Hyelim
Diamond, Michael S.
author_facet Cho, Hyelim
Diamond, Michael S.
author_sort Cho, Hyelim
collection PubMed
description West Nile virus (WNV) continues to cause outbreaks of severe neuroinvasive disease in humans and other vertebrate animals in the United States, Europe, and other regions of the world. This review discusses our understanding of the interactions between virus and host that occur in the central nervous system (CNS), the outcome of which can be protection, viral pathogenesis, or immunopathogenesis. We will focus on defining the current state of knowledge of WNV entry, tropism, and host immune response in the CNS, all of which affect the balance between injury and successful clearance.
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spelling pubmed-35282922013-01-02 Immune Responses to West Nile Virus Infection in the Central Nervous System Cho, Hyelim Diamond, Michael S. Viruses Review West Nile virus (WNV) continues to cause outbreaks of severe neuroinvasive disease in humans and other vertebrate animals in the United States, Europe, and other regions of the world. This review discusses our understanding of the interactions between virus and host that occur in the central nervous system (CNS), the outcome of which can be protection, viral pathogenesis, or immunopathogenesis. We will focus on defining the current state of knowledge of WNV entry, tropism, and host immune response in the CNS, all of which affect the balance between injury and successful clearance. MDPI 2012-12-17 /pmc/articles/PMC3528292/ /pubmed/23247502 http://dx.doi.org/10.3390/v4123812 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Cho, Hyelim
Diamond, Michael S.
Immune Responses to West Nile Virus Infection in the Central Nervous System
title Immune Responses to West Nile Virus Infection in the Central Nervous System
title_full Immune Responses to West Nile Virus Infection in the Central Nervous System
title_fullStr Immune Responses to West Nile Virus Infection in the Central Nervous System
title_full_unstemmed Immune Responses to West Nile Virus Infection in the Central Nervous System
title_short Immune Responses to West Nile Virus Infection in the Central Nervous System
title_sort immune responses to west nile virus infection in the central nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528292/
https://www.ncbi.nlm.nih.gov/pubmed/23247502
http://dx.doi.org/10.3390/v4123812
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