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Intracellular Delivery of Short Interfering RNA in Rat Organ of Corti Using a Cell-penetrating Peptide PepFect6

RNA interference (RNAi) using short interfering RNA (siRNA) is an attractive therapeutic approach for treatment of dominant-negative mutations. Some rare missense dominant-negative mutations lead to congenital-hearing impairments. A variety of viral vectors have been tested with variable efficacy fo...

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Detalles Bibliográficos
Autores principales: Dash-Wagh, Suvarna, Jacob, Stefan, Lindberg, Staffan, Fridberger, Anders, Langel, Ülo, Ulfendahl, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528302/
https://www.ncbi.nlm.nih.gov/pubmed/23232329
http://dx.doi.org/10.1038/mtna.2012.50