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Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence

BACKGROUND: This is an update of a previous meta-analysis published in 2005. METHODS: It includes the data published up to march 2010 for a total of 247 papers and 18,300 cases. Cognitive deficits are examined in 5 different domains: Memory functioning (128 studies), Global cognitive functioning (13...

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Autores principales: Fioravanti, Mario, Bianchi, Valentina, Cinti, Maria Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528440/
https://www.ncbi.nlm.nih.gov/pubmed/22715980
http://dx.doi.org/10.1186/1471-244X-12-64
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author Fioravanti, Mario
Bianchi, Valentina
Cinti, Maria Elena
author_facet Fioravanti, Mario
Bianchi, Valentina
Cinti, Maria Elena
author_sort Fioravanti, Mario
collection PubMed
description BACKGROUND: This is an update of a previous meta-analysis published in 2005. METHODS: It includes the data published up to march 2010 for a total of 247 papers and 18,300 cases. Cognitive deficits are examined in 5 different domains: Memory functioning (128 studies), Global cognitive functioning (131 studies), Language (70 studies), Executive function (67 studies), Attention (76 studies). Only controlled studies were included: patients vs. normal subjects. RESULTS: Results evidence that in all domains and in all different analyses performed within each domain, patients show a significant reduction of cognitive efficiency with respect to normal subjects. The between studies heterogeneity is very high in almost all domains. There are various sources of this heterogeneity (age, sex, sample size, type of patients, and type of measurement) which contribute to the high degree of not-overlapping information offered by the single studies. CONCLUSIONS: Our results, based on the current scientific evidence, confirm the previous findings that there is a generalized impairment of various cognitive functions in patients with schizophrenia when compared to normal cases. The modalities with which these results are obtained have not changed over the years and the more recent studies do not modify the high heterogeneity previously found between the studies. This reduces the methodological quality of the results. In order to improve the methodological quality of the studies performed in the field of cognitive deficits of patients with schizophrenia, various factors should be taken into account and better managed in designing future studies.
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spelling pubmed-35284402013-01-03 Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence Fioravanti, Mario Bianchi, Valentina Cinti, Maria Elena BMC Psychiatry Research Article BACKGROUND: This is an update of a previous meta-analysis published in 2005. METHODS: It includes the data published up to march 2010 for a total of 247 papers and 18,300 cases. Cognitive deficits are examined in 5 different domains: Memory functioning (128 studies), Global cognitive functioning (131 studies), Language (70 studies), Executive function (67 studies), Attention (76 studies). Only controlled studies were included: patients vs. normal subjects. RESULTS: Results evidence that in all domains and in all different analyses performed within each domain, patients show a significant reduction of cognitive efficiency with respect to normal subjects. The between studies heterogeneity is very high in almost all domains. There are various sources of this heterogeneity (age, sex, sample size, type of patients, and type of measurement) which contribute to the high degree of not-overlapping information offered by the single studies. CONCLUSIONS: Our results, based on the current scientific evidence, confirm the previous findings that there is a generalized impairment of various cognitive functions in patients with schizophrenia when compared to normal cases. The modalities with which these results are obtained have not changed over the years and the more recent studies do not modify the high heterogeneity previously found between the studies. This reduces the methodological quality of the results. In order to improve the methodological quality of the studies performed in the field of cognitive deficits of patients with schizophrenia, various factors should be taken into account and better managed in designing future studies. BioMed Central 2012-06-20 /pmc/articles/PMC3528440/ /pubmed/22715980 http://dx.doi.org/10.1186/1471-244X-12-64 Text en Copyright ©2012 Fioravanti et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fioravanti, Mario
Bianchi, Valentina
Cinti, Maria Elena
Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence
title Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence
title_full Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence
title_fullStr Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence
title_full_unstemmed Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence
title_short Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence
title_sort cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528440/
https://www.ncbi.nlm.nih.gov/pubmed/22715980
http://dx.doi.org/10.1186/1471-244X-12-64
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