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Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa
BACKGROUND: Mortality from trauma remains a major public health issue as it is the leading cause of death in persons aged 5 to 44 years .Uncontrolled hemorrhage and coagulopathy is responsible for over 50% of all trauma related deaths within the first 48hrs of admission. Coagulation profiles are not...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528619/ https://www.ncbi.nlm.nih.gov/pubmed/23150904 http://dx.doi.org/10.1186/1471-227X-12-16 |
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author | Mujuni, Erick Wangoda, Robert Ongom, Peter Galukande, Moses |
author_facet | Mujuni, Erick Wangoda, Robert Ongom, Peter Galukande, Moses |
author_sort | Mujuni, Erick |
collection | PubMed |
description | BACKGROUND: Mortality from trauma remains a major public health issue as it is the leading cause of death in persons aged 5 to 44 years .Uncontrolled hemorrhage and coagulopathy is responsible for over 50% of all trauma related deaths within the first 48hrs of admission. Coagulation profiles are not routinely done among trauma patients in resource limited settings and there is a paucity of data on acute traumatic coagulopathy (ATC) in sub Saharan Africa. The study was conducted to evaluate the prothrombin time and partial thromboplastin time (PT/PTT) as predictors of mortality and morbidity among major trauma patients. METHODS: A prospective cohort study was carried out, in which major trauma patients admitted in A&E department between December 2011 to April 2012 were recruited. Five (5) mls of venous blood was drawn from a convenient vein within 10 minutes of the patient’s arrival at A&E for analysis of PT/PTT. Patients were stratified into two groups by the presence/absence of coagulopathy then followed up for a 2 week period for morbidity and mortality. RESULTS: A total of 182 major trauma patients were recruited; 149 (81.9%) were males, the mean age was 29.5 years (SD 9.8). Prevalence of coagulopathy was 54% (98/182). The mean ISS for the ATC group was 36.9 and the non ATC group was 26.9 (p=0.001). Patients with ATC stayed longer in hospital 11.24 days than non ATC patients 8 days (p=0.001). ATC was strongly associated with ARI (p= 0.003). Mortality was more in the ATC group 29 deaths compared to 9 deaths in the non ATC group. PTT was a strong independent predictor of mortality. CONCLUSION: A significant proportion of major trauma patients were coagulopathic. Initial coagulation profile is useful in predicting outcomes for major trauma patients. |
format | Online Article Text |
id | pubmed-3528619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35286192013-01-03 Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa Mujuni, Erick Wangoda, Robert Ongom, Peter Galukande, Moses BMC Emerg Med Research Article BACKGROUND: Mortality from trauma remains a major public health issue as it is the leading cause of death in persons aged 5 to 44 years .Uncontrolled hemorrhage and coagulopathy is responsible for over 50% of all trauma related deaths within the first 48hrs of admission. Coagulation profiles are not routinely done among trauma patients in resource limited settings and there is a paucity of data on acute traumatic coagulopathy (ATC) in sub Saharan Africa. The study was conducted to evaluate the prothrombin time and partial thromboplastin time (PT/PTT) as predictors of mortality and morbidity among major trauma patients. METHODS: A prospective cohort study was carried out, in which major trauma patients admitted in A&E department between December 2011 to April 2012 were recruited. Five (5) mls of venous blood was drawn from a convenient vein within 10 minutes of the patient’s arrival at A&E for analysis of PT/PTT. Patients were stratified into two groups by the presence/absence of coagulopathy then followed up for a 2 week period for morbidity and mortality. RESULTS: A total of 182 major trauma patients were recruited; 149 (81.9%) were males, the mean age was 29.5 years (SD 9.8). Prevalence of coagulopathy was 54% (98/182). The mean ISS for the ATC group was 36.9 and the non ATC group was 26.9 (p=0.001). Patients with ATC stayed longer in hospital 11.24 days than non ATC patients 8 days (p=0.001). ATC was strongly associated with ARI (p= 0.003). Mortality was more in the ATC group 29 deaths compared to 9 deaths in the non ATC group. PTT was a strong independent predictor of mortality. CONCLUSION: A significant proportion of major trauma patients were coagulopathic. Initial coagulation profile is useful in predicting outcomes for major trauma patients. BioMed Central 2012-11-14 /pmc/articles/PMC3528619/ /pubmed/23150904 http://dx.doi.org/10.1186/1471-227X-12-16 Text en Copyright ©2012 Mujuni et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mujuni, Erick Wangoda, Robert Ongom, Peter Galukande, Moses Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa |
title | Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa |
title_full | Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa |
title_fullStr | Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa |
title_full_unstemmed | Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa |
title_short | Acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub Saharan Africa |
title_sort | acute traumatic coagulopathy among major trauma patients in an urban tertiary hospital in sub saharan africa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528619/ https://www.ncbi.nlm.nih.gov/pubmed/23150904 http://dx.doi.org/10.1186/1471-227X-12-16 |
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