Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

BACKGROUND: Randomized controlled trials (RCTs) may be discontinued because of apparent harm, benefit, or futility. Other RCTs are discontinued early because of insufficient recruitment. Trial discontinuation has ethical implications, because participants consent on the premise of contributing to ne...

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Detalles Bibliográficos
Autores principales: Kasenda, Benjamin, von Elm, Erik B, You, John, Blümle, Anette, Tomonaga, Yuki, Saccilotto, Ramon, Amstutz, Alain, Bengough, Theresa, Meerpohl, Jörg, Stegert, Mihaela, Tikkinen, Kari A O, Neumann, Ignacio, Carrasco-Labra, Alonso, Faulhaber, Markus, Mulla, Sohail, Mertz, Dominik, Akl, Elie A, Bassler, Dirk, Busse, Jason W, Ferreira-González, Ignacio, Lamontagne, Francois, Nordmann, Alain, Rosenthal, Rachel, Schandelmaier, Stefan, Sun, Xin, Vandvik, Per O, Johnston, Bradley C, Walter, Martin A, Burnand, Bernard, Schwenkglenks, Matthias, Bucher, Heiner C, Guyatt, Gordon H, Briel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528626/
https://www.ncbi.nlm.nih.gov/pubmed/22928744
http://dx.doi.org/10.1186/1471-2288-12-131

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