Cargando…

The importance of ubiquitination and sumoylation on the transforming activity of HTLV Tax-1 and Tax-2

Human T-cell Leukemia Virus type 1 (HTLV-1) and 2 (HTLV-2) are two closely related human retroviruses. HTLV-1 is associated with an aggressive Adult T-cell Leukemia (ATL) while there is no evidence for an association of HTLV-2 with any human malignancies. The two viruses encode transactivator protei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zane, Linda, Jeang, Kuan-Teh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Viewpoints
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528636/ https://www.ncbi.nlm.nih.gov/pubmed/23217176 http://dx.doi.org/10.1186/1742-4690-9-103

Ejemplares similares

Transformation of human embryonic stem cells by HTLV-1 Tax
por: Zane, Linda, et al.
Publicado: (2011)

NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
por: Xiao, Gutian
Publicado: (2012)

Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis
por: Zane, Linda, et al.
Publicado: (2012)

HTLV-1 Tax-induced NF-κB activation is negatively regulated by Ubiquitin-specific peptidase 20 (USP20)
por: Yasunaga, Junichiro, et al.
Publicado: (2011)

Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein
por: Turci, Marco, et al.
Publicado: (2012)

WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL?
por: Gillet, Nicolas, et al.
Publicado: (2012)

Unstabilized DNA breaks in HTLV-1 Tax expressing cells correlate with functional targeting of Ku80, not PKcs, XRCC4, or H2AX
por: Majone, Franca, et al.
Publicado: (2012)

Expression and purification of the HTLV-1 transforming protein Tax
por: Evans, Whitney, et al.
Publicado: (2011)

Distinct activities of HTLV-1 Tax1 from HTLV-2 Tax2 play key roles in pathogenesis
por: Fujii, Masahiro, et al.
Publicado: (2011)

The HTLV-1 Tax interactome
por: Boxus, Mathieu, et al.
Publicado: (2008)

Low levels of HTLV-2 Tax conjugation to ubiquitin and SUMO do not impede Tax-mediated activation of NF-κB
por: Journo, Chloé, et al.
Publicado: (2014)

Ku protein as a potential human T-cell leukemia virus type 1 (HTLV-1) Tax target in clastogenic chromosomal instability of mammalian cells
por: Majone, Franca, et al.
Publicado: (2005)

SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR
por: Kamoi, Koju, et al.
Publicado: (2006)

Mechanisms of Oncogenesis by HTLV-1 Tax
por: Mohanty, Suchitra, et al.
Publicado: (2020)

Predominant role of Tax sumoylation in Tax-induced NF-kB activation in T cells
por: Bonnet, Amandine, et al.
Publicado: (2011)

Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex
por: Ching, Yick-Pang, et al.
Publicado: (2004)

Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
por: Higuchi, Masaya, et al.
Publicado: (2009)

Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2
por: Shoji, Toshiyuki, et al.
Publicado: (2009)

The HTLV-1 oncoprotein Tax is modified by the ubiquitin related modifier 1 (Urm1)
por: Hleihel, Rita, et al.
Publicado: (2018)

HTLV Tax-1 and Tax-2 proteins enhance interferon regulatory factor 3 dependent promoter activation
por: Diani, Erica, et al.
Publicado: (2014)

The Transcription Profile of Tax-3 Is More Similar to Tax-1 than Tax-2: Insights into HTLV-3 Potential Leukemogenic Properties
por: Chevalier, Sébastien A., et al.
Publicado: (2012)

HTLV-1 Tax: centrosome amplification and cancer
por: Pumfery, Anne, et al.
Publicado: (2006)

Sugar-sweetened beverage taxes in Brazil: past, present, and future
por: Bridge, Gemma, et al.
Publicado: (2022)

Move or Die: the Fate of the Tax Oncoprotein of HTLV-1
por: Lodewick, Julie, et al.
Publicado: (2011)

Regulation of HTLV-1 Tax Stability, Cellular Trafficking and NF-κB Activation by the Ubiquitin-Proteasome Pathway
por: Lavorgna, Alfonso, et al.
Publicado: (2014)

The SUMO-targeted ubiquitin ligase RNF4 regulates localization and function of the HTLV-1 oncoprotein Tax
por: Fryrear, Kimberly A, et al.
Publicado: (2011)

HTLV-1 Tax1 represses the proapoptotic protein Bim, which is crucial for T-cell transformation
por: Higuchi, Masaya, et al.
Publicado: (2011)

Transcriptional Activity of HTLV-I Tax Influences the Expression of Marker Genes Associated with Cellular Transformation
por: Lemoine, Francene J., et al.
Publicado: (2001)

Interference of HTLV-1 Tax Protein with Cell Polarity Regulators: Defining the Subcellular Localization of the Tax-DLG1 Interaction
por: Marziali, Federico, et al.
Publicado: (2017)

The SUMOylation machinery is dispensable for Tax-induced NF-kB activation
por: Pène, Sabrina, et al.
Publicado: (2014)

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome
por: Kfoury, Youmna, et al.
Publicado: (2011)

A specificity map for HTLV-1 Tax/PDZ interactions
por: Blibek, Karim, et al.
Publicado: (2011)

An interaction map for HTLV-1 Tax and PDZ-containing proteins
por: Blibek, Karim, et al.
Publicado: (2014)

HTLV-1 Tax targets centrosomal Cep63 protein
por: Martin, Emilie, et al.
Publicado: (2015)

Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP
por: Enose-Akahata, Yoshimi, et al.
Publicado: (2017)

Effect of propolis and its active component CAPE on HTLV-1 Tax activities
por: Huleihel, Mahmoud, et al.
Publicado: (2014)

Post-translational modifications of HTLV-1 Tax carboxy-terminal domain: role in cellular transformation
por: Lodewick, Julie, et al.
Publicado: (2014)

Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo
por: Zane, Linda, et al.
Publicado: (2010)

Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model
por: Lodewick, Julie, et al.
Publicado: (2013)

The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators
por: Forlani, Greta, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_mhe917i263o7n2mg4u0gmndt6k