Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization

Increasing evidence suggests that chromosomal regions containing microRNAs are functionally important in cancers. Here, we show that genomic loci encoding miR-204 are frequently lost in multiple cancers, including ovarian cancers, pediatric renal tumors, and breast cancers. MiR-204 shows drastically...

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Detalles Bibliográficos
Autores principales: Imam, J. Saadi, Plyler, Jason R., Bansal, Hima, Prajapati, Suresh, Bansal, Sanjay, Rebeles, Jennifer, Chen, Hung-I Harry, Chang, Yao-Fu, Panneerdoss, Subbarayalu, Zoghi, Behyar, Buddavarapu, Kalyan C., Broaddus, Russell, Hornsby, Peter, Tomlinson, Gail, Dome, Jeffrey, Vadlamudi, Ratna K., Pertsemlidis, Alexander, Chen, Yidong, Rao, Manjeet K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528651/
https://www.ncbi.nlm.nih.gov/pubmed/23285024
http://dx.doi.org/10.1371/journal.pone.0052397

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