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G6f-Like Is an ITAM-Containing Collagen Receptor in Thrombocytes
Collagen activates mammalian platelets through a complex of the immunoglobulin (Ig) receptor GPVI and the Fc receptor γ-chain, which has an immunoreceptor tyrosine-based activation motif (ITAM). Cross-linking of GPVI mediates activation through the sequential activation of Src and Syk family kinases...
Autores principales: | Hughes, Craig E., Radhakrishnan, Uvaraj P., Lordkipanidzé, Marie, Egginton, Stuart, Dijkstra, Johannes M., Jagadeeswaran, Pudur, Watson, Stephen P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528668/ https://www.ncbi.nlm.nih.gov/pubmed/23285115 http://dx.doi.org/10.1371/journal.pone.0052622 |
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