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Robust Immunity and Heterologous Protection against Influenza in Mice Elicited by a Novel Recombinant NP-M2e Fusion Protein Expressed in E. coli

BACKGROUND: The 23-amino acid extracellular domain of matrix 2 protein (M2e) and the internal nucleoprotein (NP) of influenza are highly conserved among viruses and thus are promising candidate antigens for the development of a universal influenza vaccine. Various M2e- or NP-based DNA or viral vecto...

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Detalles Bibliográficos
Autores principales:	Wang, Wenling, Huang, Baoying, Jiang, Tao, Wang, Xiuping, Qi, Xiangrong, Gao, Yingying, Tan, Wenjie, Ruan, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528677/ https://www.ncbi.nlm.nih.gov/pubmed/23285063 http://dx.doi.org/10.1371/journal.pone.0052488

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