Hypertension-Linked Mutation of α-Adducin Increases CFTR Surface Expression and Activity in HEK and Cultured Rat Distal Convoluted Tubule Cells

The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity and localization are influenced by the cytoskeleton, in particular by actin and its polymerization state. In this study we investigated whether the expression of the hypertensive mutations of α-adducin (G460W-S586C in humans, F3...

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Detalles Bibliográficos
Autores principales: Mondini, Anna, Sassone, Francesca, Civello, Davide Antonio, Garavaglia, Maria Lisa, Bazzini, Claudia, Rodighiero, Simona, Vezzoli, Valeria, Conti, Fabio, Torielli, Lucia, Capasso, Giovanbattista, Paulmichl, Markus, Meyer, Giuliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528715/
https://www.ncbi.nlm.nih.gov/pubmed/23284854
http://dx.doi.org/10.1371/journal.pone.0052014

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