The Mutation V42M Distorts the Compact Packing of the Human Gamma-S-Crystallin Molecule, Resulting in Congenital Cataract

BACKGROUND: Human γS-crystallin is an important component of the human eye lens nucleus and cortex. The mutation V42M in the molecule causes severe congenital cataract in children. We compare the structure of the mutant protein with that of the wild type in order to understand how structural changes...

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Detalles Bibliográficos
Autores principales: Vendra, Venkata Pulla Rao, Chandani, Sushil, Balasubramanian, Dorairajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528740/
https://www.ncbi.nlm.nih.gov/pubmed/23284690
http://dx.doi.org/10.1371/journal.pone.0051401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528740/
https://www.ncbi.nlm.nih.gov/pubmed/23284690
http://dx.doi.org/10.1371/journal.pone.0051401

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