Cargando…

Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa

BACKGROUND: Recent studies show that activated factor VII (FVIIa) binds to the endothelial cell protein C receptor (EPCR) on the vascular endothelium; however, the importance of this interaction in hemostasis or pathophysiology is unknown. OBJECTIVE: The aim of the present study was to investigate t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clark, C A, Vatsyayan, R, Hedner, U, Esmon, C T, Pendurthi, U R, Rao, L V M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Vascular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528836/ https://www.ncbi.nlm.nih.gov/pubmed/22950420 http://dx.doi.org/10.1111/j.1538-7836.2012.04917.x

Ejemplares similares

Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa
por: Nayak, Ramesh C., et al.
Publicado: (2013)

Inactivation of Factor VIIa by Antithrombin In Vitro, Ex Vivo and In Vivo: Role of Tissue Factor and Endothelial Cell Protein C Receptor
por: Vatsyayan, Rit, et al.
Publicado: (2014)

A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis
por: Kondreddy, Vijay, et al.
Publicado: (2020)

Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells
por: Jafarnejad, M., et al.
Publicado: (2015)

Role of Tissue Factor in Mycobacterium tuberculosis-Induced Inflammation and Disease Pathogenesis
por: Kothari, Hema, et al.
Publicado: (2014)

Endothelial characteristics in healthy endothelial colony forming cells; generating a robust and valid ex vivo model for vascular disease
por: de Boer, Suzan, et al.
Publicado: (2020)

Tuning the endothelial response: differential release of exocytic cargos from Weibel‐Palade bodies
por: Nightingale, T. D., et al.
Publicado: (2018)

Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells
por: Nightingale, Thomas D., et al.
Publicado: (2009)

Variability of von Willebrand factor‐related parameters in endothelial colony forming cells
por: de Jong, Annika, et al.
Publicado: (2019)

Human endothelial cells size‐select their secretory granules for exocytosis to modulate their functional output
por: McCormack, Jessica J., et al.
Publicado: (2019)

Antithrombin protects against Plasmodium falciparum histidine-rich protein II-mediated inflammation and coagulation
por: Biswas, Indranil, et al.
Publicado: (2022)

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm
por: Castiglione, Melissa, et al.
Publicado: (2020)

Defective VWF secretion due to expression of MYH9-RD E1841K mutant in endothelial cells disrupts hemostasis
por: Cao, Yang, et al.
Publicado: (2022)

Engineering of a membrane-triggered activity switch in coagulation factor VIIa
por: Nielsen, Anders L., et al.
Publicado: (2017)

G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis
por: Stevenson, N L, et al.
Publicado: (2014)

Intrapleural Adenoviral-mediated Endothelial Cell Protein C Receptor Gene Transfer Suppresses the Progression of Malignant Pleural Mesothelioma in a Mouse Model
por: Keshava, Shiva, et al.
Publicado: (2016)

Violin concertos in C major, Hob. VIIa:1 ; in G major, Hob. VIIa:4 ; in A major, Hob. VIIa:3 /
por: Haydn, Joseph, 1732-1809
Publicado: (1989)

Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation
por: Globisch, Maria A., et al.
Publicado: (2022)

The Ratio of Factor VIIa:Tissue Factor Content within Microvesicles Determines the Differential Influence on Endothelial Cells
por: Madkhali, Yahya, et al.
Publicado: (2019)

Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCβ phosphorylation of occludin
por: Goncalves, Andreia, et al.
Publicado: (2022)

Role of von Willebrand factor and ADAMTS‐13 in early brain injury after experimental subarachnoid hemorrhage
por: Wan, H., et al.
Publicado: (2018)

Factor VIIa for severe cardiac surgical bleeding
por: Diprose, P, et al.
Publicado: (2002)

Platelet‐borne complement proteins and their role in platelet–bacteria interactions
por: Arbesu, I., et al.
Publicado: (2016)

Thrombin in complex with dabigatran can still interact with PAR‐1 via exosite‐I and instigate loss of vascular integrity
por: Dólleman, Sophie C., et al.
Publicado: (2022)

Neutrophil granulocyte-dependent proteolysis enhances platelet adhesion to the arterial wall under high-shear flow
por: WOHNER, N, et al.
Publicado: (2010)

Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations
por: Diorio, Caroline, et al.
Publicado: (2020)

PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus
por: Antoniak, Silvio, et al.
Publicado: (2021)

Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate
por: van Gorp, Rick H., et al.
Publicado: (2021)

Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP)
por: Zollner, S, et al.
Publicado: (2014)

Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa
por: Fan, Fushun, et al.
Publicado: (2017)

Factor VIIa Regulates the Level of Cell-Surface Tissue Factor through Separate but Cooperative Mechanisms
por: Madkhali, Yahya, et al.
Publicado: (2021)

Venous endothelial function in cardiovascular disease
por: Dardi, Patrizia, et al.
Publicado: (2022)

Preclinical trauma studies of recombinant factor VIIa
por: Schreiber, Martin A, et al.
Publicado: (2005)

Strengths and weaknesses of a new mouse model of thrombosis induced by inferior vena cava stenosis: communication from the SSC of the ISTH
por: Geddings, J, et al.
Publicado: (2014)

Dynamic angiopoietin-2 assessment predicts survival and chronic course in hospitalized patients with COVID-19
por: Villa, Erica, et al.
Publicado: (2021)

Risks associated with discontinuation of oral anticoagulation in newly diagnosed patients with atrial fibrillation: Results from the GARFIELD‐AF Registry
por: Cools, Frank, et al.
Publicado: (2021)

WPBs: making a mark and leaving a trail
por: Carter, Tom, et al.
Publicado: (2019)

GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies
por: Kat, Marije, et al.
Publicado: (2021)

Cerebral vascular injury in transplant-associated thrombotic microangiopathy
por: Sabulski, Anthony, et al.
Publicado: (2022)

Sustained VWF‐ADAMTS‐13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction
por: Fogarty, Helen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cvplfshdjgebulvfhutf880lmh