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Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma

BACKGROUND: The seventh edition of the TNM classification separates extrahepatic bile duct tumors into perihilar and distal tumors and further changes the definition of the TNM classification. The impact of the seventh edition on stage-based prognostic prediction for patients with perihilar cholangi...

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Autores principales: Juntermanns, Benjamin, Sotiropoulos, Georgios Charalambos, Radunz, Sonia, Reis, Henning, Heuer, Matthias, Baba, Hideo Andreas, Canbay, Ali, Schuler, Martin, Gerken, Guido, Paul, Andreas, Kaiser, Gernot Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528958/
https://www.ncbi.nlm.nih.gov/pubmed/22805862
http://dx.doi.org/10.1245/s10434-012-2486-0
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author Juntermanns, Benjamin
Sotiropoulos, Georgios Charalambos
Radunz, Sonia
Reis, Henning
Heuer, Matthias
Baba, Hideo Andreas
Canbay, Ali
Schuler, Martin
Gerken, Guido
Paul, Andreas
Kaiser, Gernot Maximilian
author_facet Juntermanns, Benjamin
Sotiropoulos, Georgios Charalambos
Radunz, Sonia
Reis, Henning
Heuer, Matthias
Baba, Hideo Andreas
Canbay, Ali
Schuler, Martin
Gerken, Guido
Paul, Andreas
Kaiser, Gernot Maximilian
author_sort Juntermanns, Benjamin
collection PubMed
description BACKGROUND: The seventh edition of the TNM classification separates extrahepatic bile duct tumors into perihilar and distal tumors and further changes the definition of the TNM classification. The impact of the seventh edition on stage-based prognostic prediction for patients with perihilar cholangiocarcinoma was evaluated. METHODS: Between January 1998 and March 2010, 223 consecutive patients with perihilar cholangiocarcinoma underwent surgery at the West German Cancer Center. Median survival times were calculated for the 195 evaluable patients (excluding those with in-hospital mortality) after separate classification by both sixth and seventh editions. RESULTS: Median overall survival was increased in patients classified using the seventh compared with the sixth edition (UICC I: 56.5 vs 23.75 months; II: 45.9 vs 31.6 months; III: 21.3 vs. 8.76 months; IV: 7.03 vs 5.93 months). The T category of the seventh edition did not alter median survival times of T1 (54.07 months) and T4 (7.83 months) cases, but median survival was prolonged for T2 patients (29.4 vs 31.6 months), and shortened for T3 patients (19.43 vs 11.8 months) staged using the seventh edition. According to Cox proportional hazards regression analysis, patient survival was better predicted by the seventh edition UICC stage and pT categories (p = 0.0014 and p = 0.0396, respectively), than the corresponding sixth edition categories (p = 0.4376 and p = 0.0926, respectively). CONCLUSIONS: The UICC seventh edition TNM classification for perihilar cholangiocarcinoma improves separation of patients with intermediate stage tumors compared with the sixth edition. The prognostic value of the UICC staging system has been strengthened by the introduction of the seventh edition.
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spelling pubmed-35289582013-01-03 Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma Juntermanns, Benjamin Sotiropoulos, Georgios Charalambos Radunz, Sonia Reis, Henning Heuer, Matthias Baba, Hideo Andreas Canbay, Ali Schuler, Martin Gerken, Guido Paul, Andreas Kaiser, Gernot Maximilian Ann Surg Oncol Hepatobiliary Tumors BACKGROUND: The seventh edition of the TNM classification separates extrahepatic bile duct tumors into perihilar and distal tumors and further changes the definition of the TNM classification. The impact of the seventh edition on stage-based prognostic prediction for patients with perihilar cholangiocarcinoma was evaluated. METHODS: Between January 1998 and March 2010, 223 consecutive patients with perihilar cholangiocarcinoma underwent surgery at the West German Cancer Center. Median survival times were calculated for the 195 evaluable patients (excluding those with in-hospital mortality) after separate classification by both sixth and seventh editions. RESULTS: Median overall survival was increased in patients classified using the seventh compared with the sixth edition (UICC I: 56.5 vs 23.75 months; II: 45.9 vs 31.6 months; III: 21.3 vs. 8.76 months; IV: 7.03 vs 5.93 months). The T category of the seventh edition did not alter median survival times of T1 (54.07 months) and T4 (7.83 months) cases, but median survival was prolonged for T2 patients (29.4 vs 31.6 months), and shortened for T3 patients (19.43 vs 11.8 months) staged using the seventh edition. According to Cox proportional hazards regression analysis, patient survival was better predicted by the seventh edition UICC stage and pT categories (p = 0.0014 and p = 0.0396, respectively), than the corresponding sixth edition categories (p = 0.4376 and p = 0.0926, respectively). CONCLUSIONS: The UICC seventh edition TNM classification for perihilar cholangiocarcinoma improves separation of patients with intermediate stage tumors compared with the sixth edition. The prognostic value of the UICC staging system has been strengthened by the introduction of the seventh edition. Springer-Verlag 2012-07-18 2013 /pmc/articles/PMC3528958/ /pubmed/22805862 http://dx.doi.org/10.1245/s10434-012-2486-0 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Hepatobiliary Tumors
Juntermanns, Benjamin
Sotiropoulos, Georgios Charalambos
Radunz, Sonia
Reis, Henning
Heuer, Matthias
Baba, Hideo Andreas
Canbay, Ali
Schuler, Martin
Gerken, Guido
Paul, Andreas
Kaiser, Gernot Maximilian
Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma
title Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma
title_full Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma
title_fullStr Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma
title_full_unstemmed Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma
title_short Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma
title_sort comparison of the sixth and the seventh editions of the uicc classification for perihilar cholangiocarcinoma
topic Hepatobiliary Tumors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528958/
https://www.ncbi.nlm.nih.gov/pubmed/22805862
http://dx.doi.org/10.1245/s10434-012-2486-0
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