Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells

During inflammation, myeloperoxidase (MPO) released by circulating leukocytes accumulates within the subendothelial matrix by binding to and transcytosing the vascular endothelium. Oxidative reactions catalyzed by subendothelial-localized MPO are implicated as a cause of endothelial dysfunction in v...

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Detalles Bibliográficos
Autores principales: Rees, Martin D., Dang, Lei, Thai, Thuan, Owen, Dylan M., Malle, Ernst, Thomas, Shane R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2012
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529214/
https://www.ncbi.nlm.nih.gov/pubmed/23059132
http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529214/
https://www.ncbi.nlm.nih.gov/pubmed/23059132
http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.002

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