Cargando…

Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation

BMI1 is a potent inducer of neural stem cell self-renewal and neural progenitor cell proliferation during development and in adult tissue homeostasis. It is overexpressed in numerous human cancers – including medulloblastomas, in which its functional role is unclear. We generated transgenic mouse li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Behesti, Hourinaz, Bhagat, Heeta, Dubuc, Adrian M., Taylor, Michael D., Marino, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529338/ https://www.ncbi.nlm.nih.gov/pubmed/23065639 http://dx.doi.org/10.1242/dmm.009506

Ejemplares similares

Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells
por: Behesti, Hourinaz, et al.
Publicado: (2021)

YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog - dependent cerebellar granule neuron progenitor cells and medulloblastoma cells
por: Dey, Abhinav, et al.
Publicado: (2016)

Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion
por: Merve, Ashirwad, et al.
Publicado: (2014)

MEDB-11. MYC overexpression and SMARCA4 loss in cerebellar granule cell precursors cooperate to drive medulloblastoma formation in mice
por: Göbel, Carolin, et al.
Publicado: (2022)

N-cadherin provides a cis and trans ligand for astrotactin that functions in glial-guided neuronal migration
por: Horn, Zachi, et al.
Publicado: (2018)

WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation
por: Anne, Sandrine L., et al.
Publicado: (2013)

Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma
por: Badodi, Sara, et al.
Publicado: (2017)

The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup
por: Behesti, Hourinaz, et al.
Publicado: (2006)

Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma
por: Luo, Wenqin, et al.
Publicado: (2021)

Widespread Contribution of Gdf7 Lineage to Cerebellar Cell Types and Implications for Hedgehog-Driven Medulloblastoma Formation
por: Cheng, Frances Y., et al.
Publicado: (2012)

Sonic Hedgehog-Induced Histone Deacetylase Activation Is Required for Cerebellar Granule Precursor Hyperplasia in Medulloblastoma
por: Lee, Seung Joon, et al.
Publicado: (2013)

Medulloblastoma or not? Crucial role in tumorigenesis of the timing of migration of cerebellar granule precursor cells, regulated by Nos2 and Tis21
por: Farioli-Vecchioli, Stefano, et al.
Publicado: (2013)

Functional characterization of acid-sensing ion channels in the cerebellum-originating medulloblastoma cell line DAOY and in cerebellar granule neurons
por: Pissas, Karolos-Philippos, et al.
Publicado: (2023)

Otx2 promotes granule cell precursor proliferation and Shh-dependent medulloblastoma maintenance in vivo
por: El Nagar, Salsabiel, et al.
Publicado: (2018)

Adult hemispheric cerebellar medulloblastoma
por: de Oliveira, Felipe, et al.
Publicado: (2018)

microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma
por: Pal, Rekha, et al.
Publicado: (2015)

Bmi1, medulloblastoma and regenerative therapy
Publicado: (2013)

LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration
por: Men, Yuqin, et al.
Publicado: (2015)

Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma
por: Badodi, Sara, et al.
Publicado: (2022)

MEDB-60. Medulloblastoma with extensive nodularity mimics cerebellar development and differentiates along the granular precursor lineage
por: Ghasemi, David R, et al.
Publicado: (2022)

Extra-Axial Medulloblastoma in the Cerebellar Hemisphere
por: Chung, Eui Jin, et al.
Publicado: (2014)

Cerebellar Medulloblastoma in Middle-to-Late Adulthood
por: Aljoghaiman, Majid, et al.
Publicado: (2018)

Cerebellar granule cells encode the expectation of reward
por: Wagner, Mark J, et al.
Publicado: (2017)

MBRS-08. SONIC HEDGEHOG SIGNALING PRIMES CEREBELLAR GRANULE NEURON PROGENITORS, THE CELL OF ORIGIN FOR MEDULLOBLASTOMA, FOR APOPTOSIS BY INDUCING PRO APOPTOTIC BIM
por: Cleveland, Abigail, et al.
Publicado: (2020)

PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth
por: Cleveland, Abigail H., et al.
Publicado: (2023)

ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins
por: Behesti, Hourinaz, et al.
Publicado: (2018)

Modeling medulloblastoma in vivo and with human cerebellar organoids
por: Ballabio, Claudio, et al.
Publicado: (2020)

Synaptic representation of locomotion in single cerebellar granule cells
por: Powell, Kate, et al.
Publicado: (2015)

Notch Signaling between Cerebellar Granule Cell Progenitors
por: Adachi, Toma, et al.
Publicado: (2021)

Regulation of cerebellar network development by granule cells and their molecules
por: Kim, Muwoong, et al.
Publicado: (2023)

The Gs-Linked Receptor GPR3 Inhibits the Proliferation of Cerebellar Granule Cells during Postnatal Development
por: Tanaka, Shigeru, et al.
Publicado: (2009)

N-myc is a key switch regulating the proliferation cycle of postnatal cerebellar granule cell progenitors
por: Ma, Ming, et al.
Publicado: (2015)

Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development
por: Miller, Tyler E., et al.
Publicado: (2014)

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells
por: Kawauchi, D, et al.
Publicado: (2017)

Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development
por: Zhang, Peter, et al.
Publicado: (2015)

MDB-23. ELP1 GERMLINE DEFICIENCY SENSITIZES THE GRANULE NEURON LINEAGE TO SHH MEDULLOBLASTOMA AND EXPOSES NOVEL THERAPEUTIC VULNERABILITIES
por: Garcia-Lopez, Jesus, et al.
Publicado: (2023)

The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma
por: Vriend, Jerry, et al.
Publicado: (2015)

Stochastic Differential Equation Model for Cerebellar Granule Cell Excitability
por: Saarinen, Antti, et al.
Publicado: (2008)

Segmental identity and cerebellar granule cell induction in rhombomere 1
por: Eddison, Mark, et al.
Publicado: (2004)

Early cerebellar granule cell migration in the mouse embryonic development
por: Chung, Seung-Hyuk, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_7lv6jjppii1nbqtlq4vgvapj27