Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology

Mutations in SEC63 cause polycystic liver disease in humans. Sec63 is a member of the endoplasmic reticulum (ER) translocon machinery, although it is unclear how mutations in SEC63 lead to liver cyst formation in humans. Here, we report the identification and characterization of a zebrafish sec63 mu...

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Detalles Bibliográficos
Autores principales: Monk, Kelly R., Voas, Matthew G., Franzini-Armstrong, Clara, Hakkinen, Ian S., Talbot, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529346/
https://www.ncbi.nlm.nih.gov/pubmed/22864019
http://dx.doi.org/10.1242/dmm.009217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529346/
https://www.ncbi.nlm.nih.gov/pubmed/22864019
http://dx.doi.org/10.1242/dmm.009217

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