Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice

A subset of patients with Parkinson’s disease acquires a debilitating dementia characterized by severe cognitive impairments (i.e. Parkinson’s disease dementia; PDD). Brains from PDD patients show extensive cholinergic loss as well as dopamine (DA) depletion. We used a mutant mouse model to directly...

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Detalles Bibliográficos
Autores principales: Zurkovsky, Lilia, Bychkov, Evgeny, Tsakem, Elviche L., Siedlecki, Carley, Blakely, Randy D., Gurevich, Eugenia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529349/
https://www.ncbi.nlm.nih.gov/pubmed/22864020
http://dx.doi.org/10.1242/dmm.010363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529349/
https://www.ncbi.nlm.nih.gov/pubmed/22864020
http://dx.doi.org/10.1242/dmm.010363

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