A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions

The actin-bundling protein fascin is a key mediator of tumor invasion and metastasis and its activity drives filopodia formation, cell-shape changes and cell migration. Small-molecule inhibitors of fascin block tumor metastasis in animal models. Conversely, fascin deficiency might underlie the patho...

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Detalles Bibliográficos
Autores principales: Kraft, Robert, Kahn, Allon, Medina-Franco, José L., Orlowski, Mikayla L., Baynes, Cayla, López-Vallejo, Fabian, Barnard, Kobus, Maggiora, Gerald M., Restifo, Linda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529353/
https://www.ncbi.nlm.nih.gov/pubmed/22917928
http://dx.doi.org/10.1242/dmm.008243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529353/
https://www.ncbi.nlm.nih.gov/pubmed/22917928
http://dx.doi.org/10.1242/dmm.008243

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