Cargando…
A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions
The actin-bundling protein fascin is a key mediator of tumor invasion and metastasis and its activity drives filopodia formation, cell-shape changes and cell migration. Small-molecule inhibitors of fascin block tumor metastasis in animal models. Conversely, fascin deficiency might underlie the patho...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Limited
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529353/ https://www.ncbi.nlm.nih.gov/pubmed/22917928 http://dx.doi.org/10.1242/dmm.008243 |