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Filling the Silent Void: Genetic Therapies for Hearing Impairment
The inner ear cytoarchitecture forms one of the most intricate and delicate organs in the human body and is vulnerable to the effects of genetic disorders, aging, and environmental damage. Owing to the inability of the mammalian cochlea to regenerate sensory hair cells, the loss of hair cells is a l...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529436/ https://www.ncbi.nlm.nih.gov/pubmed/23304527 http://dx.doi.org/10.1155/2012/748698 |
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author | Sng, Joel Lufkin, Thomas |
author_facet | Sng, Joel Lufkin, Thomas |
author_sort | Sng, Joel |
collection | PubMed |
description | The inner ear cytoarchitecture forms one of the most intricate and delicate organs in the human body and is vulnerable to the effects of genetic disorders, aging, and environmental damage. Owing to the inability of the mammalian cochlea to regenerate sensory hair cells, the loss of hair cells is a leading cause of deafness in humans. Millions of individuals worldwide are affected by the emotionally and financially devastating effects of hearing impairment (HI). This paper provides a brief introduction into the key role of genes regulating inner ear development and function. Potential future therapies that leverage on an improved understanding of these molecular pathways are also described in detail. |
format | Online Article Text |
id | pubmed-3529436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35294362013-01-09 Filling the Silent Void: Genetic Therapies for Hearing Impairment Sng, Joel Lufkin, Thomas Genet Res Int Review Article The inner ear cytoarchitecture forms one of the most intricate and delicate organs in the human body and is vulnerable to the effects of genetic disorders, aging, and environmental damage. Owing to the inability of the mammalian cochlea to regenerate sensory hair cells, the loss of hair cells is a leading cause of deafness in humans. Millions of individuals worldwide are affected by the emotionally and financially devastating effects of hearing impairment (HI). This paper provides a brief introduction into the key role of genes regulating inner ear development and function. Potential future therapies that leverage on an improved understanding of these molecular pathways are also described in detail. Hindawi Publishing Corporation 2012 2012-12-04 /pmc/articles/PMC3529436/ /pubmed/23304527 http://dx.doi.org/10.1155/2012/748698 Text en Copyright © 2012 J. Sng and T. Lufkin. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sng, Joel Lufkin, Thomas Filling the Silent Void: Genetic Therapies for Hearing Impairment |
title | Filling the Silent Void: Genetic Therapies for Hearing Impairment |
title_full | Filling the Silent Void: Genetic Therapies for Hearing Impairment |
title_fullStr | Filling the Silent Void: Genetic Therapies for Hearing Impairment |
title_full_unstemmed | Filling the Silent Void: Genetic Therapies for Hearing Impairment |
title_short | Filling the Silent Void: Genetic Therapies for Hearing Impairment |
title_sort | filling the silent void: genetic therapies for hearing impairment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529436/ https://www.ncbi.nlm.nih.gov/pubmed/23304527 http://dx.doi.org/10.1155/2012/748698 |
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