Cargando…

Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin-Signaling Deficiency

Obesity has been considered one of the leading causative agents for diseases such as type 2 diabetes, stroke, and heart attack. Due to their complex etiology, establishing auseful animal model is increasingly crucial for better molecular understanding of how obesity influences on disease development...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kose, Hiroyuki, Yamada, Takahisa, Matsumoto, Kozo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529458/ https://www.ncbi.nlm.nih.gov/pubmed/23304119 http://dx.doi.org/10.1155/2012/858121

Ejemplares similares

Genetic Dissection of Complex Genetic Factor Involved in NIDDM of OLETF Rat
por: Yamada, Takahisa, et al.
Publicado: (2012)

Beneficial Effects of Thiazolidinediones on Diabetic Nephropathy in OLETF Rats
por: Lee, Mi Young, et al.
Publicado: (2007)

An Atherogenic Paigen-Diet Aggravates Nephropathy in Type 2 Diabetic OLETF Rats
por: Nozako, Masanori, et al.
Publicado: (2015)

Microarray for Genes Associated with Signal Transduction in Diabetic OLETF Keratocytes
por: Lee, Ji-Eun, et al.
Publicado: (2007)

Microarray Analysis for Genes Associated with Angiogenesis in Diabetic OLETF Keratocytes
por: Park, Jun-Mo, et al.
Publicado: (2014)

Use of Drosophila as an Evaluation Method Reveals imp as a Candidate Gene for Type 2 Diabetes in Rat Locus Niddm22
por: Kawasaki, Kurenai, et al.
Publicado: (2015)

Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes
por: Kim, Kyoung Soo, et al.
Publicado: (2012)

Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats
por: Marunaka, Yoshinori, et al.
Publicado: (2014)

Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy
por: Guo, Zhenhong, et al.
Publicado: (2021)

Alpha-lipoic acid preserves skeletal muscle mass in type 2 diabetic OLETF rats
por: Hong, Oak-Kee, et al.
Publicado: (2018)

Animal Models of Diabetes and Metabolic Disease
por: Sasase, Tomohiko, et al.
Publicado: (2013)

Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats
por: Nakano, Daisuke, et al.
Publicado: (2011)

1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats
por: Watanabe, Ayako, et al.
Publicado: (2020)

Salsalate Prevents β-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway
por: Han, Fei, et al.
Publicado: (2019)

Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts
por: Ogawa, Toshifumi, et al.
Publicado: (2023)

Laser induced injury caused hyperglycemia-like effect in Drosophila larva: a possible insect model for posttraumatic diabetes
por: OKABE, Fumio, et al.
Publicado: (2015)

Effects of acupuncture stimulation on blood glucose concentration in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model for type-2 diabetes mellitus
por: Nakamura, Hironori, et al.
Publicado: (2014)

Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats: Paradoxical Roles of Hyperglycemia and Insulin
por: Zhong, Mei-Fang, et al.
Publicado: (2012)

Insulin and glucagon secretions, and morphological change of pancreatic islets in OLETF rats, a model of type 2 diabetes mellitus.
por: Hong, Eun Gyoung, et al.
Publicado: (2002)

Insulin‐Stimulated Bone Blood Flow and Bone Biomechanical Properties Are Compromised in Obese, Type 2 Diabetic OLETF Rats
por: Dirkes, Rebecca K, et al.
Publicado: (2017)

Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice
por: Naito, Masaki, et al.
Publicado: (2011)

Leptin- and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes
por: Wang, Bingxuan, et al.
Publicado: (2014)

Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula)
por: Zhang, Haojun, et al.
Publicado: (2011)

Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats
por: Hwang, Yoo-Cheol, et al.
Publicado: (2018)

Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats
por: Nagao, Koji, et al.
Publicado: (2013)

Effects of early postnatal environment on hypothalamic gene expression in OLETF rats
por: Kim, Yonwook J., et al.
Publicado: (2017)

Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
por: German, Jonathan P., et al.
Publicado: (2010)

Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats
por: Nishimura, Norihisa, et al.
Publicado: (2018)

Anti-Diabetic Effect of Organo-Chalcogen (Sulfur and Selenium) Zinc Complexes with Hydroxy-Pyrone Derivatives on Leptin-Deficient Type 2 Diabetes Model ob/ob Mice
por: Nishiguchi, Takayuki, et al.
Publicado: (2017)

Leptin, diabetes, and the brain
por: Meek, Thomas H., et al.
Publicado: (2012)

Acupuncture Alters Expression of Insulin Signaling Related Molecules and Improves Insulin Resistance in OLETF Rats
por: Huang, Xin-Yu, et al.
Publicado: (2016)

Leptin and Nutrition in Gestational Diabetes
por: Pérez-Pérez, Antonio, et al.
Publicado: (2020)

Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency
por: Li, Xinhua, et al.
Publicado: (2020)

Vascular Aldosterone Production at the Pre-Diabetic Stage of Young Otsuka Long-Evans Tokushima Fatty (OLETF) Rats, Compared with Long-Evans Tokushima Otsuka (LETO) Rats
por: Matsuzawa, Yoko, et al.
Publicado: (2013)

Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity
por: Yupanqui-Lozno, Hernan, et al.
Publicado: (2019)

‘Fat’s chances’: Loci for phenotypic dispersion in plasma leptin in mouse models of diabetes mellitus
por: Perry, Guy M. L.
Publicado: (2019)

Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin
por: Ito, Yoshihiro, et al.
Publicado: (2022)

The Association of Serum Leptin Level and Anthropometric Measures With the Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus
por: Afarid, Mehrdad, et al.
Publicado: (2018)

Exercise and Omega-3 Polyunsaturated Fatty Acid Supplementation for the Treatment of Hepatic Steatosis in Hyperphagic OLETF Rats
por: Borengasser, Sarah J., et al.
Publicado: (2012)

Anti-Proliferative Effects of Rutin on OLETF Rat Vascular Smooth Muscle Cells Stimulated by Glucose Variability
por: Yu, Sung Hoon, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_f605pekqkaetbj5mp8n68a41b3