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Mitochondria Superoxide Anion Production Contributes to Geranylgeraniol-Induced Death in Leishmania amazonensis

Here we demonstrate the activity of geranylgeraniol, the major bioactive constituent from seeds of Bixa orellana, against Leishmania amazonensis. Geranylgeraniol was identified through (1)H and (13)C nuclear magnetic resonance imaging and DEPT. The compound inhibited the promastigote and intracellul...

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Detalles Bibliográficos
Autores principales:	Lopes, Milene Valéria, Desoti, Vânia Cristina, Caleare, Angelo de Oliveira, Ueda-Nakamura, Tânia, Silva, Sueli Oliveira, Nakamura, Celso Vataru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529489/ https://www.ncbi.nlm.nih.gov/pubmed/23304195 http://dx.doi.org/10.1155/2012/298320

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