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Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)

Mannose-binding lectin is a central molecule of the innate immune system. Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis. However, contradictory results among different populations have been reported, resulting in no c...

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Autores principales: Ocejo-Vinyals, J.-Gonzalo, Lavín-Alconero, Lucía, Sánchez-Velasco, Pablo, Guerrero-Alonso, M.-Ángeles, Ausín, Fernando, Fariñas, M.-Carmen, Leyva-Cobián, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529500/
https://www.ncbi.nlm.nih.gov/pubmed/23304495
http://dx.doi.org/10.1155/2012/469128
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author Ocejo-Vinyals, J.-Gonzalo
Lavín-Alconero, Lucía
Sánchez-Velasco, Pablo
Guerrero-Alonso, M.-Ángeles
Ausín, Fernando
Fariñas, M.-Carmen
Leyva-Cobián, Francisco
author_facet Ocejo-Vinyals, J.-Gonzalo
Lavín-Alconero, Lucía
Sánchez-Velasco, Pablo
Guerrero-Alonso, M.-Ángeles
Ausín, Fernando
Fariñas, M.-Carmen
Leyva-Cobián, Francisco
author_sort Ocejo-Vinyals, J.-Gonzalo
collection PubMed
description Mannose-binding lectin is a central molecule of the innate immune system. Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis. However, contradictory results among different populations have been reported, resulting in no convincing evidence of association between mannose-binding lectin 2 and susceptibility to tuberculosis. For this reason, we conducted a study in a well genetically conserved Spanish population in order to shed light on this controversial association. We analysed the six promoter and structural mannose-binding lectin 2 gene variants in 107 patients with pulmonary tuberculosis and 441 healthy controls. Only D variant and HYPD haplotype were significantly more frequents in controls which would indicate that this allele could confer protection against pulmonary tuberculosis, but this difference disappeared after statistical correction. Neither the rest of alleles nor the haplotypes were significantly associated with the disease. These results would indicate that mannose-binding lectin promoter polymorphisms and gene variants would not be associated with an increased risk to pulmonary tuberculosis. Despite the slight trend of the D allele and HYPD haplotype in conferring protection against pulmonary tuberculosis, susceptibility to this disease would probably be due to other genetic factors, at least in our population.
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spelling pubmed-35295002013-01-09 Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain) Ocejo-Vinyals, J.-Gonzalo Lavín-Alconero, Lucía Sánchez-Velasco, Pablo Guerrero-Alonso, M.-Ángeles Ausín, Fernando Fariñas, M.-Carmen Leyva-Cobián, Francisco Pulm Med Research Article Mannose-binding lectin is a central molecule of the innate immune system. Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis. However, contradictory results among different populations have been reported, resulting in no convincing evidence of association between mannose-binding lectin 2 and susceptibility to tuberculosis. For this reason, we conducted a study in a well genetically conserved Spanish population in order to shed light on this controversial association. We analysed the six promoter and structural mannose-binding lectin 2 gene variants in 107 patients with pulmonary tuberculosis and 441 healthy controls. Only D variant and HYPD haplotype were significantly more frequents in controls which would indicate that this allele could confer protection against pulmonary tuberculosis, but this difference disappeared after statistical correction. Neither the rest of alleles nor the haplotypes were significantly associated with the disease. These results would indicate that mannose-binding lectin promoter polymorphisms and gene variants would not be associated with an increased risk to pulmonary tuberculosis. Despite the slight trend of the D allele and HYPD haplotype in conferring protection against pulmonary tuberculosis, susceptibility to this disease would probably be due to other genetic factors, at least in our population. Hindawi Publishing Corporation 2012 2012-12-04 /pmc/articles/PMC3529500/ /pubmed/23304495 http://dx.doi.org/10.1155/2012/469128 Text en Copyright © 2012 J.-Gonzalo Ocejo-Vinyals et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ocejo-Vinyals, J.-Gonzalo
Lavín-Alconero, Lucía
Sánchez-Velasco, Pablo
Guerrero-Alonso, M.-Ángeles
Ausín, Fernando
Fariñas, M.-Carmen
Leyva-Cobián, Francisco
Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)
title Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)
title_full Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)
title_fullStr Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)
title_full_unstemmed Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)
title_short Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)
title_sort mannose-binding lectin promoter polymorphisms and gene variants in pulmonary tuberculosis patients from cantabria (northern spain)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529500/
https://www.ncbi.nlm.nih.gov/pubmed/23304495
http://dx.doi.org/10.1155/2012/469128
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