Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network

Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident...

Descripción completa

Detalles Bibliográficos
Autores principales: von Blume, Julia, Alleaume, Anne-Marie, Kienzle, Christine, Carreras-Sureda, Amado, Valverde, Miguel, Malhotra, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529532/
https://www.ncbi.nlm.nih.gov/pubmed/23266954
http://dx.doi.org/10.1083/jcb.201207180
_version_ 1782253931198414848
author von Blume, Julia
Alleaume, Anne-Marie
Kienzle, Christine
Carreras-Sureda, Amado
Valverde, Miguel
Malhotra, Vivek
author_facet von Blume, Julia
Alleaume, Anne-Marie
Kienzle, Christine
Carreras-Sureda, Amado
Valverde, Miguel
Malhotra, Vivek
author_sort von Blume, Julia
collection PubMed
description Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca(2+) import into the TGN; it binds secretory cargo in a Ca(2+)-dependent reaction and is required for its sorting at the TGN.
format Online
Article
Text
id pubmed-3529532
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-35295322013-06-24 Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network von Blume, Julia Alleaume, Anne-Marie Kienzle, Christine Carreras-Sureda, Amado Valverde, Miguel Malhotra, Vivek J Cell Biol Research Articles Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca(2+) import into the TGN; it binds secretory cargo in a Ca(2+)-dependent reaction and is required for its sorting at the TGN. The Rockefeller University Press 2012-12-24 /pmc/articles/PMC3529532/ /pubmed/23266954 http://dx.doi.org/10.1083/jcb.201207180 Text en © 2012 von Blume et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Research Articles
von Blume, Julia
Alleaume, Anne-Marie
Kienzle, Christine
Carreras-Sureda, Amado
Valverde, Miguel
Malhotra, Vivek
Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network
title Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network
title_full Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network
title_fullStr Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network
title_full_unstemmed Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network
title_short Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network
title_sort cab45 is required for ca(2+)-dependent secretory cargo sorting at the trans-golgi network
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529532/
https://www.ncbi.nlm.nih.gov/pubmed/23266954
http://dx.doi.org/10.1083/jcb.201207180
work_keys_str_mv AT vonblumejulia cab45isrequiredforca2dependentsecretorycargosortingatthetransgolginetwork
AT alleaumeannemarie cab45isrequiredforca2dependentsecretorycargosortingatthetransgolginetwork
AT kienzlechristine cab45isrequiredforca2dependentsecretorycargosortingatthetransgolginetwork
AT carrerassuredaamado cab45isrequiredforca2dependentsecretorycargosortingatthetransgolginetwork
AT valverdemiguel cab45isrequiredforca2dependentsecretorycargosortingatthetransgolginetwork
AT malhotravivek cab45isrequiredforca2dependentsecretorycargosortingatthetransgolginetwork

Ejemplares similares