Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2(3) factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tabl...

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Detalles Bibliográficos
Autores principales: Malakar, Jadupati, Nayak, Amit Kumar, Goswami, Soumita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529867/
https://www.ncbi.nlm.nih.gov/pubmed/23378933
http://dx.doi.org/10.5402/2012/730624
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author Malakar, Jadupati
Nayak, Amit Kumar
Goswami, Soumita
author_facet Malakar, Jadupati
Nayak, Amit Kumar
Goswami, Soumita
author_sort Malakar, Jadupati
collection PubMed
description The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2(3) factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release and hardness were analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized bisoprolol fumarate matrix tablets showed prolonged sustained release of bisoprolol fumarate over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.
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spelling pubmed-35298672013-02-01 Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release Malakar, Jadupati Nayak, Amit Kumar Goswami, Soumita ISRN Pharm Research Article The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2(3) factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release and hardness were analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized bisoprolol fumarate matrix tablets showed prolonged sustained release of bisoprolol fumarate over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism. International Scholarly Research Network 2012-12-10 /pmc/articles/PMC3529867/ /pubmed/23378933 http://dx.doi.org/10.5402/2012/730624 Text en Copyright © 2012 Jadupati Malakar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Malakar, Jadupati
Nayak, Amit Kumar
Goswami, Soumita
Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
title Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
title_full Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
title_fullStr Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
title_full_unstemmed Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
title_short Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
title_sort use of response surface methodology in the formulation and optimization of bisoprolol fumarate matrix tablets for sustained drug release
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529867/
https://www.ncbi.nlm.nih.gov/pubmed/23378933
http://dx.doi.org/10.5402/2012/730624
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