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Metabolic Syndrome, Obesity, and Gastrointestinal Cancer
Metabolic syndrome is a cluster of metabolic abnormalities and is defined as the presence of three or more of the following factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose. Obesity, which is accom...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530232/ https://www.ncbi.nlm.nih.gov/pubmed/23304125 http://dx.doi.org/10.1155/2012/483623 |
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author | Fujihara, Shintaro Mori, Hirohito Kobara, Hideki Nishiyama, Noriko Kobayashi, Mitsuyoshi Oryu, Makoto Masaki, Tsutomu |
author_facet | Fujihara, Shintaro Mori, Hirohito Kobara, Hideki Nishiyama, Noriko Kobayashi, Mitsuyoshi Oryu, Makoto Masaki, Tsutomu |
author_sort | Fujihara, Shintaro |
collection | PubMed |
description | Metabolic syndrome is a cluster of metabolic abnormalities and is defined as the presence of three or more of the following factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose. Obesity, which is accompanied by metabolic dysregulation often manifested in the metabolic syndrome, is an established risk factor for many cancers. Adipose tissue, particularly visceral fat, is an important metabolic tissue as it secretes systemic factors that alter the immunologic, metabolic, and endocrine milieu and also promotes insulin resistance. Within the growth-promoting, proinflammatory environment of the obese state, cross-talk between macrophages, adipocytes, and epithelial cells occurs via obesity-associated hormones, adipocytokines, and other mediators that may enhance cancer risk and progression. This paper synthesizes the evidence on key molecular mechanisms underlying the obesity-cancer link. |
format | Online Article Text |
id | pubmed-3530232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35302322013-01-09 Metabolic Syndrome, Obesity, and Gastrointestinal Cancer Fujihara, Shintaro Mori, Hirohito Kobara, Hideki Nishiyama, Noriko Kobayashi, Mitsuyoshi Oryu, Makoto Masaki, Tsutomu Gastroenterol Res Pract Review Article Metabolic syndrome is a cluster of metabolic abnormalities and is defined as the presence of three or more of the following factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose. Obesity, which is accompanied by metabolic dysregulation often manifested in the metabolic syndrome, is an established risk factor for many cancers. Adipose tissue, particularly visceral fat, is an important metabolic tissue as it secretes systemic factors that alter the immunologic, metabolic, and endocrine milieu and also promotes insulin resistance. Within the growth-promoting, proinflammatory environment of the obese state, cross-talk between macrophages, adipocytes, and epithelial cells occurs via obesity-associated hormones, adipocytokines, and other mediators that may enhance cancer risk and progression. This paper synthesizes the evidence on key molecular mechanisms underlying the obesity-cancer link. Hindawi Publishing Corporation 2012 2012-12-11 /pmc/articles/PMC3530232/ /pubmed/23304125 http://dx.doi.org/10.1155/2012/483623 Text en Copyright © 2012 Shintaro Fujihara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fujihara, Shintaro Mori, Hirohito Kobara, Hideki Nishiyama, Noriko Kobayashi, Mitsuyoshi Oryu, Makoto Masaki, Tsutomu Metabolic Syndrome, Obesity, and Gastrointestinal Cancer |
title | Metabolic Syndrome, Obesity, and Gastrointestinal Cancer |
title_full | Metabolic Syndrome, Obesity, and Gastrointestinal Cancer |
title_fullStr | Metabolic Syndrome, Obesity, and Gastrointestinal Cancer |
title_full_unstemmed | Metabolic Syndrome, Obesity, and Gastrointestinal Cancer |
title_short | Metabolic Syndrome, Obesity, and Gastrointestinal Cancer |
title_sort | metabolic syndrome, obesity, and gastrointestinal cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530232/ https://www.ncbi.nlm.nih.gov/pubmed/23304125 http://dx.doi.org/10.1155/2012/483623 |
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