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Metabolic Syndrome, Obesity, and Gastrointestinal Cancer

Metabolic syndrome is a cluster of metabolic abnormalities and is defined as the presence of three or more of the following factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose. Obesity, which is accom...

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Detalles Bibliográficos
Autores principales: Fujihara, Shintaro, Mori, Hirohito, Kobara, Hideki, Nishiyama, Noriko, Kobayashi, Mitsuyoshi, Oryu, Makoto, Masaki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530232/
https://www.ncbi.nlm.nih.gov/pubmed/23304125
http://dx.doi.org/10.1155/2012/483623
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author Fujihara, Shintaro
Mori, Hirohito
Kobara, Hideki
Nishiyama, Noriko
Kobayashi, Mitsuyoshi
Oryu, Makoto
Masaki, Tsutomu
author_facet Fujihara, Shintaro
Mori, Hirohito
Kobara, Hideki
Nishiyama, Noriko
Kobayashi, Mitsuyoshi
Oryu, Makoto
Masaki, Tsutomu
author_sort Fujihara, Shintaro
collection PubMed
description Metabolic syndrome is a cluster of metabolic abnormalities and is defined as the presence of three or more of the following factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose. Obesity, which is accompanied by metabolic dysregulation often manifested in the metabolic syndrome, is an established risk factor for many cancers. Adipose tissue, particularly visceral fat, is an important metabolic tissue as it secretes systemic factors that alter the immunologic, metabolic, and endocrine milieu and also promotes insulin resistance. Within the growth-promoting, proinflammatory environment of the obese state, cross-talk between macrophages, adipocytes, and epithelial cells occurs via obesity-associated hormones, adipocytokines, and other mediators that may enhance cancer risk and progression. This paper synthesizes the evidence on key molecular mechanisms underlying the obesity-cancer link.
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spelling pubmed-35302322013-01-09 Metabolic Syndrome, Obesity, and Gastrointestinal Cancer Fujihara, Shintaro Mori, Hirohito Kobara, Hideki Nishiyama, Noriko Kobayashi, Mitsuyoshi Oryu, Makoto Masaki, Tsutomu Gastroenterol Res Pract Review Article Metabolic syndrome is a cluster of metabolic abnormalities and is defined as the presence of three or more of the following factors: increased waist circumference, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose. Obesity, which is accompanied by metabolic dysregulation often manifested in the metabolic syndrome, is an established risk factor for many cancers. Adipose tissue, particularly visceral fat, is an important metabolic tissue as it secretes systemic factors that alter the immunologic, metabolic, and endocrine milieu and also promotes insulin resistance. Within the growth-promoting, proinflammatory environment of the obese state, cross-talk between macrophages, adipocytes, and epithelial cells occurs via obesity-associated hormones, adipocytokines, and other mediators that may enhance cancer risk and progression. This paper synthesizes the evidence on key molecular mechanisms underlying the obesity-cancer link. Hindawi Publishing Corporation 2012 2012-12-11 /pmc/articles/PMC3530232/ /pubmed/23304125 http://dx.doi.org/10.1155/2012/483623 Text en Copyright © 2012 Shintaro Fujihara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fujihara, Shintaro
Mori, Hirohito
Kobara, Hideki
Nishiyama, Noriko
Kobayashi, Mitsuyoshi
Oryu, Makoto
Masaki, Tsutomu
Metabolic Syndrome, Obesity, and Gastrointestinal Cancer
title Metabolic Syndrome, Obesity, and Gastrointestinal Cancer
title_full Metabolic Syndrome, Obesity, and Gastrointestinal Cancer
title_fullStr Metabolic Syndrome, Obesity, and Gastrointestinal Cancer
title_full_unstemmed Metabolic Syndrome, Obesity, and Gastrointestinal Cancer
title_short Metabolic Syndrome, Obesity, and Gastrointestinal Cancer
title_sort metabolic syndrome, obesity, and gastrointestinal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530232/
https://www.ncbi.nlm.nih.gov/pubmed/23304125
http://dx.doi.org/10.1155/2012/483623
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