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Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for Production of K(V)1.3 Channel Blockers

The K(v)1.3 voltage-gated potassium channel regulates membrane potential and calcium signaling in human effector memory T cells that are key mediators of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Thus, subtype-specific K(v)1.3 blockers have potential...

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Detalles Bibliográficos
Autores principales:	Anangi, Raveendra, Koshy, Shyny, Huq, Redwan, Beeton, Christine, Chuang, Woei-Jer, King, Glenn F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530466/ https://www.ncbi.nlm.nih.gov/pubmed/23300835 http://dx.doi.org/10.1371/journal.pone.0052965

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