Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression

When grown in 3D cultures as spheroids, mesothelioma cells acquire a multicellular resistance to apoptosis that resembles that of solid tumors. We have previously found that resistance to the proteasome inhibitor bortezomib in 3D can be explained by a lack of upregulation of Noxa, the pro-apoptotic...

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Detalles Bibliográficos
Autores principales: Barbone, Dario, Cheung, Priscilla, Battula, Sailaja, Busacca, Sara, Gray, Steven G., Longley, Daniel B., Bueno, Raphael, Sugarbaker, David J., Fennell, Dean A., Broaddus, V. Courtney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530471/
https://www.ncbi.nlm.nih.gov/pubmed/23300762
http://dx.doi.org/10.1371/journal.pone.0052753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530471/
https://www.ncbi.nlm.nih.gov/pubmed/23300762
http://dx.doi.org/10.1371/journal.pone.0052753

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