Combined Inhibition of IGF-1R/IR and Src Family Kinases Enhances Antitumor Effects in Prostate Cancer by Decreasing Activated Survival Pathways

BACKGROUND: Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa results in improved tumor inhibition. The Src family kinases (SFK) and insulin-like growth factor-1 (IGF-1) signaling axes are abe...

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Detalles Bibliográficos
Autores principales: Dayyani, Farshid, Parikh, Nila U., Varkaris, Andreas S., Song, Jian H., Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N., Wolfe, Adam R., Carboni, Joan M., Gottardis, Marco M., Logothetis, Christopher J., Gallick, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530555/
https://www.ncbi.nlm.nih.gov/pubmed/23300537
http://dx.doi.org/10.1371/journal.pone.0051189

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