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Design, Synthesis, and In Vitro and In Vivo Biological Studies of a 3′-Deoxythymidine Conjugate that Potentially Kills Cancer Cells Selectively

Thymidine kinases (TKs) have been considered one of the potential targets for anticancer therapeutic because of their elevated expressions in cancer cells. However, nucleobase analogs targeting TKs have shown poor selective cytotoxicity in cancer cells despite effective antiviral activity. 3′-Deoxyt...

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Detalles Bibliográficos
Autores principales:	Wei, Qiong, Zhang, Dejun, Yao, Anna, Mai, Liyi, Zhang, Zhiwei, Zhou, Qibing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530607/ https://www.ncbi.nlm.nih.gov/pubmed/23300611 http://dx.doi.org/10.1371/journal.pone.0052199

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