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Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes

BACKGROUND: Brachial-ankle pulse wave velocity (baPWV) is known to be a good surrogate marker of clinical atherosclerosis. Atherosclerosis is a major predictor for developing neuropathy. The goal of this study was to determine the relationship between baPWV and diabetic peripheral neuropathy (DPN) i...

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Autores principales: Ha, Byung Kil, Kim, Bong Gun, Kim, Dong Hyun, Lee, Soon Il, Jung, Soon Myung, Park, Ja Young, Lee, Chang Won, Kim, Sang Soo, Kim, Bo Hyun, Kim, In Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530715/
https://www.ncbi.nlm.nih.gov/pubmed/23275938
http://dx.doi.org/10.4093/dmj.2012.36.6.443
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author Ha, Byung Kil
Kim, Bong Gun
Kim, Dong Hyun
Lee, Soon Il
Jung, Soon Myung
Park, Ja Young
Lee, Chang Won
Kim, Sang Soo
Kim, Bo Hyun
Kim, In Ju
author_facet Ha, Byung Kil
Kim, Bong Gun
Kim, Dong Hyun
Lee, Soon Il
Jung, Soon Myung
Park, Ja Young
Lee, Chang Won
Kim, Sang Soo
Kim, Bo Hyun
Kim, In Ju
author_sort Ha, Byung Kil
collection PubMed
description BACKGROUND: Brachial-ankle pulse wave velocity (baPWV) is known to be a good surrogate marker of clinical atherosclerosis. Atherosclerosis is a major predictor for developing neuropathy. The goal of this study was to determine the relationship between baPWV and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes. METHODS: A retrospective cross-sectional study was conducted involving 692 patients with type 2 diabetes. The correlation between increased baPWV and DPN, neurological symptoms, and neurological assessment was analyzed. DPN was examined using the total symptom score (TSS), ankle reflexes, the vibration test, and the 10-g monofilament test. DPN was defined as TSS ≥2 and an abnormal neurological assessment. Data were expressed as means±standard deviation for normally distributed data and as median (interquartile range) for non-normally distributed data. Independent t-tests or chi-square tests were used to make comparisons between groups, and a multiple logistic regression test was used to evaluate independent predictors of DPN. The Mantel-Haenszel chi-square test was used to adjust for age. RESULTS: Patients with DPN had higher baPWV and systolic blood pressure, and were more likely to be older and female, when compared to the control group. According to univariate analysis of risk factors for DPN, the odds ratio of the baPWV ≥1,600 cm/sec was 1.611 (95% confidence interval [CI], 1.072 to 2.422; P=0.021) and the odds ratio in female was 1.816 (95% CI, 1.195 to 2.760; P=0.005). CONCLUSION: Increased baPWV was significantly correlated with peripheral neuropathy in patients with type 2 diabetes.
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spelling pubmed-35307152012-12-28 Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes Ha, Byung Kil Kim, Bong Gun Kim, Dong Hyun Lee, Soon Il Jung, Soon Myung Park, Ja Young Lee, Chang Won Kim, Sang Soo Kim, Bo Hyun Kim, In Ju Diabetes Metab J Original Article BACKGROUND: Brachial-ankle pulse wave velocity (baPWV) is known to be a good surrogate marker of clinical atherosclerosis. Atherosclerosis is a major predictor for developing neuropathy. The goal of this study was to determine the relationship between baPWV and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes. METHODS: A retrospective cross-sectional study was conducted involving 692 patients with type 2 diabetes. The correlation between increased baPWV and DPN, neurological symptoms, and neurological assessment was analyzed. DPN was examined using the total symptom score (TSS), ankle reflexes, the vibration test, and the 10-g monofilament test. DPN was defined as TSS ≥2 and an abnormal neurological assessment. Data were expressed as means±standard deviation for normally distributed data and as median (interquartile range) for non-normally distributed data. Independent t-tests or chi-square tests were used to make comparisons between groups, and a multiple logistic regression test was used to evaluate independent predictors of DPN. The Mantel-Haenszel chi-square test was used to adjust for age. RESULTS: Patients with DPN had higher baPWV and systolic blood pressure, and were more likely to be older and female, when compared to the control group. According to univariate analysis of risk factors for DPN, the odds ratio of the baPWV ≥1,600 cm/sec was 1.611 (95% confidence interval [CI], 1.072 to 2.422; P=0.021) and the odds ratio in female was 1.816 (95% CI, 1.195 to 2.760; P=0.005). CONCLUSION: Increased baPWV was significantly correlated with peripheral neuropathy in patients with type 2 diabetes. Korean Diabetes Association 2012-12 2012-12-12 /pmc/articles/PMC3530715/ /pubmed/23275938 http://dx.doi.org/10.4093/dmj.2012.36.6.443 Text en Copyright © 2012 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ha, Byung Kil
Kim, Bong Gun
Kim, Dong Hyun
Lee, Soon Il
Jung, Soon Myung
Park, Ja Young
Lee, Chang Won
Kim, Sang Soo
Kim, Bo Hyun
Kim, In Ju
Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes
title Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes
title_full Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes
title_fullStr Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes
title_full_unstemmed Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes
title_short Relationships between Brachial-Ankle Pulse Wave Velocity and Peripheral Neuropathy in Type 2 Diabetes
title_sort relationships between brachial-ankle pulse wave velocity and peripheral neuropathy in type 2 diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530715/
https://www.ncbi.nlm.nih.gov/pubmed/23275938
http://dx.doi.org/10.4093/dmj.2012.36.6.443
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