Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient

We report a female patient with rheumatoid arthritis which was refractory to methotrexate, leflunomide, and anti-TNF therapy. She was treated with anti-IL-6 tocilizumab (TCZ), with an early appearance of sterile pustules on erythematous swollen skin of trunk, back, and abdominal area. The lesions we...

Descripción completa

Detalles Bibliográficos
Autores principales: Izquierdo, J. H., Bonilla-Abadía, F., Ochoa, C. D., Agualimpia, A., Tobón, G. J., Cañas, C. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530750/
https://www.ncbi.nlm.nih.gov/pubmed/23304614
http://dx.doi.org/10.1155/2012/517424
_version_ 1782254058779705344
author Izquierdo, J. H.
Bonilla-Abadía, F.
Ochoa, C. D.
Agualimpia, A.
Tobón, G. J.
Cañas, C. A.
author_facet Izquierdo, J. H.
Bonilla-Abadía, F.
Ochoa, C. D.
Agualimpia, A.
Tobón, G. J.
Cañas, C. A.
author_sort Izquierdo, J. H.
collection PubMed
description We report a female patient with rheumatoid arthritis which was refractory to methotrexate, leflunomide, and anti-TNF therapy. She was treated with anti-IL-6 tocilizumab (TCZ), with an early appearance of sterile pustules on erythematous swollen skin of trunk, back, and abdominal area. The lesions were consistent with the diagnosis of acute drug-related generalized exanthematous pustulosis (AGEP). This adverse event was controlled with medical treatment without requiring removal of TCZ.
format Online
Article
Text
id pubmed-3530750
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35307502013-01-09 Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient Izquierdo, J. H. Bonilla-Abadía, F. Ochoa, C. D. Agualimpia, A. Tobón, G. J. Cañas, C. A. Case Rep Rheumatol Case Report We report a female patient with rheumatoid arthritis which was refractory to methotrexate, leflunomide, and anti-TNF therapy. She was treated with anti-IL-6 tocilizumab (TCZ), with an early appearance of sterile pustules on erythematous swollen skin of trunk, back, and abdominal area. The lesions were consistent with the diagnosis of acute drug-related generalized exanthematous pustulosis (AGEP). This adverse event was controlled with medical treatment without requiring removal of TCZ. Hindawi Publishing Corporation 2012 2012-12-12 /pmc/articles/PMC3530750/ /pubmed/23304614 http://dx.doi.org/10.1155/2012/517424 Text en Copyright © 2012 J. H. Izquierdo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Izquierdo, J. H.
Bonilla-Abadía, F.
Ochoa, C. D.
Agualimpia, A.
Tobón, G. J.
Cañas, C. A.
Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient
title Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient
title_full Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient
title_fullStr Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient
title_full_unstemmed Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient
title_short Acute Generalized Exanthematous Pustulosis due to Tocilizumab in a Rheumatoid Arthritis Patient
title_sort acute generalized exanthematous pustulosis due to tocilizumab in a rheumatoid arthritis patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530750/
https://www.ncbi.nlm.nih.gov/pubmed/23304614
http://dx.doi.org/10.1155/2012/517424
work_keys_str_mv AT izquierdojh acutegeneralizedexanthematouspustulosisduetotocilizumabinarheumatoidarthritispatient
AT bonillaabadiaf acutegeneralizedexanthematouspustulosisduetotocilizumabinarheumatoidarthritispatient
AT ochoacd acutegeneralizedexanthematouspustulosisduetotocilizumabinarheumatoidarthritispatient
AT agualimpiaa acutegeneralizedexanthematouspustulosisduetotocilizumabinarheumatoidarthritispatient
AT tobongj acutegeneralizedexanthematouspustulosisduetotocilizumabinarheumatoidarthritispatient
AT canasca acutegeneralizedexanthematouspustulosisduetotocilizumabinarheumatoidarthritispatient

Ejemplares similares