Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance

Interactions between the aromatic amino acid residues have a significant influence on the protein structures and protein-DNA complexes. These interactions individually provide little stability to the structure; however, together they contribute significantly to the conformational stability of the pr...

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Autores principales: Anjana, Ramnath, Vaishnavi, Marthandan Kirti, Sherlin, Durairaj, Kumar, Surapaneni Pavan, Naveen, Kora, Kanth, Pasam Sandeep, Sekar, Kanagaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2012
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530875/
https://www.ncbi.nlm.nih.gov/pubmed/23275723
http://dx.doi.org/10.6026/97320630081220
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author Anjana, Ramnath
Vaishnavi, Marthandan Kirti
Sherlin, Durairaj
Kumar, Surapaneni Pavan
Naveen, Kora
Kanth, Pasam Sandeep
Sekar, Kanagaraj
author_facet Anjana, Ramnath
Vaishnavi, Marthandan Kirti
Sherlin, Durairaj
Kumar, Surapaneni Pavan
Naveen, Kora
Kanth, Pasam Sandeep
Sekar, Kanagaraj
author_sort Anjana, Ramnath
collection PubMed
description Interactions between the aromatic amino acid residues have a significant influence on the protein structures and protein-DNA complexes. These interactions individually provide little stability to the structure; however, together they contribute significantly to the conformational stability of the protein structure. In this study, we focus on the four aromatic amino acid residues and their interactions with one another and their individual interactions with the four nucleotide bases. These are analyzed in order to determine the extent to which their orientation and the number of interactions contribute to the protein and protein-DNA complex structures.
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spelling pubmed-35308752012-12-28 Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance Anjana, Ramnath Vaishnavi, Marthandan Kirti Sherlin, Durairaj Kumar, Surapaneni Pavan Naveen, Kora Kanth, Pasam Sandeep Sekar, Kanagaraj Bioinformation Hypothesis Interactions between the aromatic amino acid residues have a significant influence on the protein structures and protein-DNA complexes. These interactions individually provide little stability to the structure; however, together they contribute significantly to the conformational stability of the protein structure. In this study, we focus on the four aromatic amino acid residues and their interactions with one another and their individual interactions with the four nucleotide bases. These are analyzed in order to determine the extent to which their orientation and the number of interactions contribute to the protein and protein-DNA complex structures. Biomedical Informatics 2012-12-08 /pmc/articles/PMC3530875/ /pubmed/23275723 http://dx.doi.org/10.6026/97320630081220 Text en © 2012 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Anjana, Ramnath
Vaishnavi, Marthandan Kirti
Sherlin, Durairaj
Kumar, Surapaneni Pavan
Naveen, Kora
Kanth, Pasam Sandeep
Sekar, Kanagaraj
Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance
title Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance
title_full Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance
title_fullStr Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance
title_full_unstemmed Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance
title_short Aromatic-aromatic interactions in structures of proteins and protein-DNA complexes: a study based on orientation and distance
title_sort aromatic-aromatic interactions in structures of proteins and protein-dna complexes: a study based on orientation and distance
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530875/
https://www.ncbi.nlm.nih.gov/pubmed/23275723
http://dx.doi.org/10.6026/97320630081220
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