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DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters

This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important a...

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Detalles Bibliográficos
Autores principales: Ichikawa, Natsuko, Sasagawa, Machi, Yamamoto, Mika, Komaki, Hisayuki, Yoshida, Yumi, Yamazaki, Shuji, Fujita, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531092/
https://www.ncbi.nlm.nih.gov/pubmed/23185043
http://dx.doi.org/10.1093/nar/gks1177
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author Ichikawa, Natsuko
Sasagawa, Machi
Yamamoto, Mika
Komaki, Hisayuki
Yoshida, Yumi
Yamazaki, Shuji
Fujita, Nobuyuki
author_facet Ichikawa, Natsuko
Sasagawa, Machi
Yamamoto, Mika
Komaki, Hisayuki
Yoshida, Yumi
Yamazaki, Shuji
Fujita, Nobuyuki
author_sort Ichikawa, Natsuko
collection PubMed
description This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters.
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spelling pubmed-35310922013-03-07 DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters Ichikawa, Natsuko Sasagawa, Machi Yamamoto, Mika Komaki, Hisayuki Yoshida, Yumi Yamazaki, Shuji Fujita, Nobuyuki Nucleic Acids Res Articles This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters. Oxford University Press 2013-01 2012-11-25 /pmc/articles/PMC3531092/ /pubmed/23185043 http://dx.doi.org/10.1093/nar/gks1177 Text en © The Author(s) 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Articles
Ichikawa, Natsuko
Sasagawa, Machi
Yamamoto, Mika
Komaki, Hisayuki
Yoshida, Yumi
Yamazaki, Shuji
Fujita, Nobuyuki
DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
title DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
title_full DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
title_fullStr DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
title_full_unstemmed DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
title_short DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters
title_sort dobiscuit: a database of secondary metabolite biosynthetic gene clusters
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531092/
https://www.ncbi.nlm.nih.gov/pubmed/23185043
http://dx.doi.org/10.1093/nar/gks1177
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