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ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics

ZFIN, the Zebrafish Model Organism Database (http://zfin.org), is the central resource for zebrafish genetic, genomic, phenotypic and developmental data. ZFIN curators manually curate and integrate comprehensive data involving zebrafish genes, mutants, transgenics, phenotypes, genotypes, gene expres...

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Autores principales: Howe, Douglas G., Bradford, Yvonne M., Conlin, Tom, Eagle, Anne E., Fashena, David, Frazer, Ken, Knight, Jonathan, Mani, Prita, Martin, Ryan, Moxon, Sierra A. Taylor, Paddock, Holly, Pich, Christian, Ramachandran, Sridhar, Ruef, Barbara J., Ruzicka, Leyla, Schaper, Kevin, Shao, Xiang, Singer, Amy, Sprunger, Brock, Van Slyke, Ceri E., Westerfield, Monte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531097/
https://www.ncbi.nlm.nih.gov/pubmed/23074187
http://dx.doi.org/10.1093/nar/gks938
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author Howe, Douglas G.
Bradford, Yvonne M.
Conlin, Tom
Eagle, Anne E.
Fashena, David
Frazer, Ken
Knight, Jonathan
Mani, Prita
Martin, Ryan
Moxon, Sierra A. Taylor
Paddock, Holly
Pich, Christian
Ramachandran, Sridhar
Ruef, Barbara J.
Ruzicka, Leyla
Schaper, Kevin
Shao, Xiang
Singer, Amy
Sprunger, Brock
Van Slyke, Ceri E.
Westerfield, Monte
author_facet Howe, Douglas G.
Bradford, Yvonne M.
Conlin, Tom
Eagle, Anne E.
Fashena, David
Frazer, Ken
Knight, Jonathan
Mani, Prita
Martin, Ryan
Moxon, Sierra A. Taylor
Paddock, Holly
Pich, Christian
Ramachandran, Sridhar
Ruef, Barbara J.
Ruzicka, Leyla
Schaper, Kevin
Shao, Xiang
Singer, Amy
Sprunger, Brock
Van Slyke, Ceri E.
Westerfield, Monte
author_sort Howe, Douglas G.
collection PubMed
description ZFIN, the Zebrafish Model Organism Database (http://zfin.org), is the central resource for zebrafish genetic, genomic, phenotypic and developmental data. ZFIN curators manually curate and integrate comprehensive data involving zebrafish genes, mutants, transgenics, phenotypes, genotypes, gene expressions, morpholinos, antibodies, anatomical structures and publications. Integrated views of these data, as well as data gathered through collaborations and data exchanges, are provided through a wide selection of web-based search forms. Among the vertebrate model organisms, zebrafish are uniquely well suited for rapid and targeted generation of mutant lines. The recent rapid production of mutants and transgenic zebrafish is making management of data associated with these resources particularly important to the research community. Here, we describe recent enhancements to ZFIN aimed at improving our support for mutant and transgenic lines, including (i) enhanced mutant/transgenic search functionality; (ii) more expressive phenotype curation methods; (iii) new downloads files and archival data access; (iv) incorporation of new data loads from laboratories undertaking large-scale generation of mutant or transgenic lines and (v) new GBrowse tracks for transgenic insertions, genes with antibodies and morpholinos.
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spelling pubmed-35310972013-03-07 ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics Howe, Douglas G. Bradford, Yvonne M. Conlin, Tom Eagle, Anne E. Fashena, David Frazer, Ken Knight, Jonathan Mani, Prita Martin, Ryan Moxon, Sierra A. Taylor Paddock, Holly Pich, Christian Ramachandran, Sridhar Ruef, Barbara J. Ruzicka, Leyla Schaper, Kevin Shao, Xiang Singer, Amy Sprunger, Brock Van Slyke, Ceri E. Westerfield, Monte Nucleic Acids Res Articles ZFIN, the Zebrafish Model Organism Database (http://zfin.org), is the central resource for zebrafish genetic, genomic, phenotypic and developmental data. ZFIN curators manually curate and integrate comprehensive data involving zebrafish genes, mutants, transgenics, phenotypes, genotypes, gene expressions, morpholinos, antibodies, anatomical structures and publications. Integrated views of these data, as well as data gathered through collaborations and data exchanges, are provided through a wide selection of web-based search forms. Among the vertebrate model organisms, zebrafish are uniquely well suited for rapid and targeted generation of mutant lines. The recent rapid production of mutants and transgenic zebrafish is making management of data associated with these resources particularly important to the research community. Here, we describe recent enhancements to ZFIN aimed at improving our support for mutant and transgenic lines, including (i) enhanced mutant/transgenic search functionality; (ii) more expressive phenotype curation methods; (iii) new downloads files and archival data access; (iv) incorporation of new data loads from laboratories undertaking large-scale generation of mutant or transgenic lines and (v) new GBrowse tracks for transgenic insertions, genes with antibodies and morpholinos. Oxford University Press 2013-01 2012-10-15 /pmc/articles/PMC3531097/ /pubmed/23074187 http://dx.doi.org/10.1093/nar/gks938 Text en © The Author(s) 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Articles
Howe, Douglas G.
Bradford, Yvonne M.
Conlin, Tom
Eagle, Anne E.
Fashena, David
Frazer, Ken
Knight, Jonathan
Mani, Prita
Martin, Ryan
Moxon, Sierra A. Taylor
Paddock, Holly
Pich, Christian
Ramachandran, Sridhar
Ruef, Barbara J.
Ruzicka, Leyla
Schaper, Kevin
Shao, Xiang
Singer, Amy
Sprunger, Brock
Van Slyke, Ceri E.
Westerfield, Monte
ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
title ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
title_full ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
title_fullStr ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
title_full_unstemmed ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
title_short ZFIN, the Zebrafish Model Organism Database: increased support for mutants and transgenics
title_sort zfin, the zebrafish model organism database: increased support for mutants and transgenics
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531097/
https://www.ncbi.nlm.nih.gov/pubmed/23074187
http://dx.doi.org/10.1093/nar/gks938
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