Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides

Quorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database (http://quorumpeps.ugent.be) is developed to give a structured overview of the QS oligopep...

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Detalles Bibliográficos
Autores principales: Wynendaele, Evelien, Bronselaer, Antoon, Nielandt, Joachim, D’Hondt, Matthias, Stalmans, Sofie, Bracke, Nathalie, Verbeke, Frederick, Van De Wiele, Christophe, De Tré, Guy, De Spiegeleer, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531179/
https://www.ncbi.nlm.nih.gov/pubmed/23180797
http://dx.doi.org/10.1093/nar/gks1137
Descripción
Sumario:Quorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database (http://quorumpeps.ugent.be) is developed to give a structured overview of the QS oligopeptides, describing their microbial origin (species), functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). The chemical diversity observed within this group of QS signalling molecules can be used to develop new synthetic bio-active compounds.

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