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Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing
The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing. HAGR features now several databases with high-quality manually curated data: (i) GenAge, a database of genes asso...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531213/ https://www.ncbi.nlm.nih.gov/pubmed/23193293 http://dx.doi.org/10.1093/nar/gks1155 |
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author | Tacutu, Robi Craig, Thomas Budovsky, Arie Wuttke, Daniel Lehmann, Gilad Taranukha, Dmitri Costa, Joana Fraifeld, Vadim E. de Magalhães, João Pedro |
author_facet | Tacutu, Robi Craig, Thomas Budovsky, Arie Wuttke, Daniel Lehmann, Gilad Taranukha, Dmitri Costa, Joana Fraifeld, Vadim E. de Magalhães, João Pedro |
author_sort | Tacutu, Robi |
collection | PubMed |
description | The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing. HAGR features now several databases with high-quality manually curated data: (i) GenAge, a database of genes associated with ageing in humans and model organisms; (ii) AnAge, an extensive collection of longevity records and complementary traits for >4000 vertebrate species; and (iii) GenDR, a newly incorporated database, containing both gene mutations that interfere with dietary restriction-mediated lifespan extension and consistent gene expression changes induced by dietary restriction. Since its creation about 10 years ago, major efforts have been undertaken to maintain the quality of data in HAGR, while further continuing to develop, improve and extend it. This article briefly describes the content of HAGR and details the major updates since its previous publications, in terms of both structure and content. The completely redesigned interface, more intuitive and more integrative of HAGR resources, is also presented. Altogether, we hope that through its improvements, the current version of HAGR will continue to provide users with the most comprehensive and accessible resources available today in the field of biogerontology. |
format | Online Article Text |
id | pubmed-3531213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35312132013-03-07 Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing Tacutu, Robi Craig, Thomas Budovsky, Arie Wuttke, Daniel Lehmann, Gilad Taranukha, Dmitri Costa, Joana Fraifeld, Vadim E. de Magalhães, João Pedro Nucleic Acids Res Articles The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing. HAGR features now several databases with high-quality manually curated data: (i) GenAge, a database of genes associated with ageing in humans and model organisms; (ii) AnAge, an extensive collection of longevity records and complementary traits for >4000 vertebrate species; and (iii) GenDR, a newly incorporated database, containing both gene mutations that interfere with dietary restriction-mediated lifespan extension and consistent gene expression changes induced by dietary restriction. Since its creation about 10 years ago, major efforts have been undertaken to maintain the quality of data in HAGR, while further continuing to develop, improve and extend it. This article briefly describes the content of HAGR and details the major updates since its previous publications, in terms of both structure and content. The completely redesigned interface, more intuitive and more integrative of HAGR resources, is also presented. Altogether, we hope that through its improvements, the current version of HAGR will continue to provide users with the most comprehensive and accessible resources available today in the field of biogerontology. Oxford University Press 2013-01 2012-11-26 /pmc/articles/PMC3531213/ /pubmed/23193293 http://dx.doi.org/10.1093/nar/gks1155 Text en © The Author(s) 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com. |
spellingShingle | Articles Tacutu, Robi Craig, Thomas Budovsky, Arie Wuttke, Daniel Lehmann, Gilad Taranukha, Dmitri Costa, Joana Fraifeld, Vadim E. de Magalhães, João Pedro Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing |
title | Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing |
title_full | Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing |
title_fullStr | Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing |
title_full_unstemmed | Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing |
title_short | Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing |
title_sort | human ageing genomic resources: integrated databases and tools for the biology and genetics of ageing |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531213/ https://www.ncbi.nlm.nih.gov/pubmed/23193293 http://dx.doi.org/10.1093/nar/gks1155 |
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