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Retinitis pigmentosa and ocular blood flow

Is the concept of integrative, preventive and personalised medicine applicable to the relationship between retinitis pigmentosa (RP) and ocular blood flow (OBF)? RP encompasses a group of hereditary diseases of the posterior segment of the eye characterised by degeneration, atrophy and finally loss...

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Autores principales: Konieczka, Katarzyna, J Flammer, Andreas, Todorova, Margarita, Meyer, Peter, Flammer, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531263/
https://www.ncbi.nlm.nih.gov/pubmed/23199279
http://dx.doi.org/10.1186/1878-5085-3-17
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author Konieczka, Katarzyna
J Flammer, Andreas
Todorova, Margarita
Meyer, Peter
Flammer, Josef
author_facet Konieczka, Katarzyna
J Flammer, Andreas
Todorova, Margarita
Meyer, Peter
Flammer, Josef
author_sort Konieczka, Katarzyna
collection PubMed
description Is the concept of integrative, preventive and personalised medicine applicable to the relationship between retinitis pigmentosa (RP) and ocular blood flow (OBF)? RP encompasses a group of hereditary diseases of the posterior segment of the eye characterised by degeneration, atrophy and finally loss of photoreceptors and retinal pigment epithelium, leading to progressive visual loss. Many different mutations affecting different genes can lead to the clinical picture of RP. Even though the disease has a clear genetic background, there are obviously other factors influencing the manifestation and progression of RP. In this review, we focus on the role of OBF. There is evidence that, in PR patients, OBF is more reduced than one would expect secondary to the retinal atrophy. The main cause of this additional component seems to be primary vascular dysregulation (PVD) syndrome. As PVD syndrome is partly treatable, a vascular evaluation of RP patients is meaningful. Based on the outcome, a targeted individualised, preventive or supportive treatment might be introduced in selected RP patients.
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spelling pubmed-35312632013-01-10 Retinitis pigmentosa and ocular blood flow Konieczka, Katarzyna J Flammer, Andreas Todorova, Margarita Meyer, Peter Flammer, Josef EPMA J Review Is the concept of integrative, preventive and personalised medicine applicable to the relationship between retinitis pigmentosa (RP) and ocular blood flow (OBF)? RP encompasses a group of hereditary diseases of the posterior segment of the eye characterised by degeneration, atrophy and finally loss of photoreceptors and retinal pigment epithelium, leading to progressive visual loss. Many different mutations affecting different genes can lead to the clinical picture of RP. Even though the disease has a clear genetic background, there are obviously other factors influencing the manifestation and progression of RP. In this review, we focus on the role of OBF. There is evidence that, in PR patients, OBF is more reduced than one would expect secondary to the retinal atrophy. The main cause of this additional component seems to be primary vascular dysregulation (PVD) syndrome. As PVD syndrome is partly treatable, a vascular evaluation of RP patients is meaningful. Based on the outcome, a targeted individualised, preventive or supportive treatment might be introduced in selected RP patients. BioMed Central 2012-12-03 /pmc/articles/PMC3531263/ /pubmed/23199279 http://dx.doi.org/10.1186/1878-5085-3-17 Text en Copyright ©2012 Konieczka et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Konieczka, Katarzyna
J Flammer, Andreas
Todorova, Margarita
Meyer, Peter
Flammer, Josef
Retinitis pigmentosa and ocular blood flow
title Retinitis pigmentosa and ocular blood flow
title_full Retinitis pigmentosa and ocular blood flow
title_fullStr Retinitis pigmentosa and ocular blood flow
title_full_unstemmed Retinitis pigmentosa and ocular blood flow
title_short Retinitis pigmentosa and ocular blood flow
title_sort retinitis pigmentosa and ocular blood flow
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531263/
https://www.ncbi.nlm.nih.gov/pubmed/23199279
http://dx.doi.org/10.1186/1878-5085-3-17
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