Chapter 11: Genome-Wide Association Studies

Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic...

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Detalles Bibliográficos
Autores principales: Bush, William S., Moore, Jason H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Education
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531285/
https://www.ncbi.nlm.nih.gov/pubmed/23300413
http://dx.doi.org/10.1371/journal.pcbi.1002822
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author Bush, William S.
Moore, Jason H.
author_facet Bush, William S.
Moore, Jason H.
author_sort Bush, William S.
collection PubMed
description Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.
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spelling pubmed-35312852013-01-08 Chapter 11: Genome-Wide Association Studies Bush, William S. Moore, Jason H. PLoS Comput Biol Education Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS. Public Library of Science 2012-12-27 /pmc/articles/PMC3531285/ /pubmed/23300413 http://dx.doi.org/10.1371/journal.pcbi.1002822 Text en © 2012 Bush, Moore http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Education
Bush, William S.
Moore, Jason H.
Chapter 11: Genome-Wide Association Studies
title Chapter 11: Genome-Wide Association Studies
title_full Chapter 11: Genome-Wide Association Studies
title_fullStr Chapter 11: Genome-Wide Association Studies
title_full_unstemmed Chapter 11: Genome-Wide Association Studies
title_short Chapter 11: Genome-Wide Association Studies
title_sort chapter 11: genome-wide association studies
topic Education
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531285/
https://www.ncbi.nlm.nih.gov/pubmed/23300413
http://dx.doi.org/10.1371/journal.pcbi.1002822
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