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Molecular Mechanism of Allosteric Communication in Hsp70 Revealed by Molecular Dynamics Simulations

Investigating ligand-regulated allosteric coupling between protein domains is fundamental to understand cell-life regulation. The Hsp70 family of chaperones represents an example of proteins in which ATP binding and hydrolysis at the Nucleotide Binding Domain (NBD) modulate substrate recognition at...

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Detalles Bibliográficos
Autores principales:	Chiappori, Federica, Merelli, Ivan, Colombo, Giorgio, Milanesi, Luciano, Morra, Giulia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531320/ https://www.ncbi.nlm.nih.gov/pubmed/23300424 http://dx.doi.org/10.1371/journal.pcbi.1002844

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