Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45

Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid dec...

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Detalles Bibliográficos
Autores principales: Kuban-Jankowska, Alicja, Tuszynski, Jack A., Winter, Philip, Gorska, Magdalena, Knap, Narcyz, Wozniak, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531430/
https://www.ncbi.nlm.nih.gov/pubmed/23300686
http://dx.doi.org/10.1371/journal.pone.0052495
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author Kuban-Jankowska, Alicja
Tuszynski, Jack A.
Winter, Philip
Gorska, Magdalena
Knap, Narcyz
Wozniak, Michal
author_facet Kuban-Jankowska, Alicja
Tuszynski, Jack A.
Winter, Philip
Gorska, Magdalena
Knap, Narcyz
Wozniak, Michal
author_sort Kuban-Jankowska, Alicja
collection PubMed
description Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide.
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spelling pubmed-35314302013-01-08 Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45 Kuban-Jankowska, Alicja Tuszynski, Jack A. Winter, Philip Gorska, Magdalena Knap, Narcyz Wozniak, Michal PLoS One Research Article Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide. Public Library of Science 2012-12-27 /pmc/articles/PMC3531430/ /pubmed/23300686 http://dx.doi.org/10.1371/journal.pone.0052495 Text en © 2012 Kuban-Jankowska et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kuban-Jankowska, Alicja
Tuszynski, Jack A.
Winter, Philip
Gorska, Magdalena
Knap, Narcyz
Wozniak, Michal
Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45
title Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45
title_full Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45
title_fullStr Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45
title_full_unstemmed Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45
title_short Activation of Hydrogen Peroxide to Peroxytetradecanoic Acid Is Responsible for Potent Inhibition of Protein Tyrosine Phosphatase CD45
title_sort activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase cd45
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531430/
https://www.ncbi.nlm.nih.gov/pubmed/23300686
http://dx.doi.org/10.1371/journal.pone.0052495
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