Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

Mosaic Variegated Aneuploidy (MVA) syndrome is a rare autosomal recessive disorder characterized by inaccurate chromosome segregation and high rates of near-diploid aneuploidy. Children with MVA syndrome die at an early age, are cancer prone, and have progeroid features like facial dysmorphisms, sho...

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Detalles Bibliográficos
Autores principales: Wijshake, Tobias, Malureanu, Liviu A., Baker, Darren J., Jeganathan, Karthik B., van de Sluis, Bart, van Deursen, Jan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531486/
https://www.ncbi.nlm.nih.gov/pubmed/23300461
http://dx.doi.org/10.1371/journal.pgen.1003138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531486/
https://www.ncbi.nlm.nih.gov/pubmed/23300461
http://dx.doi.org/10.1371/journal.pgen.1003138

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