Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

BACKGROUND: Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a vaccine against filariasis may depend on...

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Detalles Bibliográficos
Autores principales: Babayan, Simon A., Luo, HongLin, Gray, Nick, Taylor, David W., Allen, Judith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531514/
https://www.ncbi.nlm.nih.gov/pubmed/23301106
http://dx.doi.org/10.1371/journal.pntd.0001968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531514/
https://www.ncbi.nlm.nih.gov/pubmed/23301106
http://dx.doi.org/10.1371/journal.pntd.0001968

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