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Neurobiological Effects of Transcranial Direct Current Stimulation: A Review

Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation technique that is affordable and easy to operate compared to other neuromodulation techniques. Anodal stimulation increases cortical excitability, while the cathodal stimulation decreases it. Although tDCS is a promis...

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Autores principales: Medeiros, Liciane Fernandes, de Souza, Izabel Cristina Custodio, Vidor, Liliane Pinto, de Souza, Andressa, Deitos, Alícia, Volz, Magdalena Sarah, Fregni, Felipe, Caumo, Wolnei, Torres, Iraci L. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531595/
https://www.ncbi.nlm.nih.gov/pubmed/23293607
http://dx.doi.org/10.3389/fpsyt.2012.00110
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author Medeiros, Liciane Fernandes
de Souza, Izabel Cristina Custodio
Vidor, Liliane Pinto
de Souza, Andressa
Deitos, Alícia
Volz, Magdalena Sarah
Fregni, Felipe
Caumo, Wolnei
Torres, Iraci L. S.
author_facet Medeiros, Liciane Fernandes
de Souza, Izabel Cristina Custodio
Vidor, Liliane Pinto
de Souza, Andressa
Deitos, Alícia
Volz, Magdalena Sarah
Fregni, Felipe
Caumo, Wolnei
Torres, Iraci L. S.
author_sort Medeiros, Liciane Fernandes
collection PubMed
description Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation technique that is affordable and easy to operate compared to other neuromodulation techniques. Anodal stimulation increases cortical excitability, while the cathodal stimulation decreases it. Although tDCS is a promising treatment approach for chronic pain as well as for neuropsychiatric diseases and other neurological disorders, several complex neurobiological mechanisms that are not well understood are involved in its effect. The purpose of this systematic review is to summarize the current knowledge regarding the neurobiological mechanisms involved in the effects of tDCS. The initial search resulted in 171 articles. After applying inclusion and exclusion criteria, we screened 32 full-text articles to extract findings about the neurobiology of tDCS effects including investigation of cortical excitability parameters. Overall, these findings show that tDCS involves a cascade of events at the cellular and molecular levels. Moreover, tDCS is associated with glutamatergic, GABAergic, dopaminergic, serotonergic, and cholinergic activity modulation. Though these studies provide important advancements toward the understanding of mechanisms underlying tDCS effects, further studies are needed to integrate these mechanisms as to optimize clinical development of tDCS.
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spelling pubmed-35315952013-01-04 Neurobiological Effects of Transcranial Direct Current Stimulation: A Review Medeiros, Liciane Fernandes de Souza, Izabel Cristina Custodio Vidor, Liliane Pinto de Souza, Andressa Deitos, Alícia Volz, Magdalena Sarah Fregni, Felipe Caumo, Wolnei Torres, Iraci L. S. Front Psychiatry Psychiatry Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation technique that is affordable and easy to operate compared to other neuromodulation techniques. Anodal stimulation increases cortical excitability, while the cathodal stimulation decreases it. Although tDCS is a promising treatment approach for chronic pain as well as for neuropsychiatric diseases and other neurological disorders, several complex neurobiological mechanisms that are not well understood are involved in its effect. The purpose of this systematic review is to summarize the current knowledge regarding the neurobiological mechanisms involved in the effects of tDCS. The initial search resulted in 171 articles. After applying inclusion and exclusion criteria, we screened 32 full-text articles to extract findings about the neurobiology of tDCS effects including investigation of cortical excitability parameters. Overall, these findings show that tDCS involves a cascade of events at the cellular and molecular levels. Moreover, tDCS is associated with glutamatergic, GABAergic, dopaminergic, serotonergic, and cholinergic activity modulation. Though these studies provide important advancements toward the understanding of mechanisms underlying tDCS effects, further studies are needed to integrate these mechanisms as to optimize clinical development of tDCS. Frontiers Media S.A. 2012-12-28 /pmc/articles/PMC3531595/ /pubmed/23293607 http://dx.doi.org/10.3389/fpsyt.2012.00110 Text en Copyright © 2012 Medeiros, de Souza, Vidor, de Souza, Deitos, Volz, Fregni, Caumo and Torres. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Psychiatry
Medeiros, Liciane Fernandes
de Souza, Izabel Cristina Custodio
Vidor, Liliane Pinto
de Souza, Andressa
Deitos, Alícia
Volz, Magdalena Sarah
Fregni, Felipe
Caumo, Wolnei
Torres, Iraci L. S.
Neurobiological Effects of Transcranial Direct Current Stimulation: A Review
title Neurobiological Effects of Transcranial Direct Current Stimulation: A Review
title_full Neurobiological Effects of Transcranial Direct Current Stimulation: A Review
title_fullStr Neurobiological Effects of Transcranial Direct Current Stimulation: A Review
title_full_unstemmed Neurobiological Effects of Transcranial Direct Current Stimulation: A Review
title_short Neurobiological Effects of Transcranial Direct Current Stimulation: A Review
title_sort neurobiological effects of transcranial direct current stimulation: a review
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531595/
https://www.ncbi.nlm.nih.gov/pubmed/23293607
http://dx.doi.org/10.3389/fpsyt.2012.00110
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