Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**

THE FIRST CELL-PENETRATING PEPTIDE: that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach...

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Detalles Bibliográficos
Autores principales: Chatterjee, Jayanta, Beullens, Monique, Sukackaite, Rasa, Qian, Junbin, Lesage, Bart, Hart, Darren J, Bollen, Mathieu, Köhn, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531619/
https://www.ncbi.nlm.nih.gov/pubmed/22962028
http://dx.doi.org/10.1002/anie.201204308
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author Chatterjee, Jayanta
Beullens, Monique
Sukackaite, Rasa
Qian, Junbin
Lesage, Bart
Hart, Darren J
Bollen, Mathieu
Köhn, Maja
author_facet Chatterjee, Jayanta
Beullens, Monique
Sukackaite, Rasa
Qian, Junbin
Lesage, Bart
Hart, Darren J
Bollen, Mathieu
Köhn, Maja
author_sort Chatterjee, Jayanta
collection PubMed
description THE FIRST CELL-PENETRATING PEPTIDE: that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach to study PP1 function and to counteract Ser/Thr kinase activity under pathologically increased kinase signaling.
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spelling pubmed-35316192013-01-04 Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells** Chatterjee, Jayanta Beullens, Monique Sukackaite, Rasa Qian, Junbin Lesage, Bart Hart, Darren J Bollen, Mathieu Köhn, Maja Angew Chem Int Ed Engl Communications THE FIRST CELL-PENETRATING PEPTIDE: that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach to study PP1 function and to counteract Ser/Thr kinase activity under pathologically increased kinase signaling. WILEY-VCH Verlag 2012-10-01 2012-09-07 /pmc/articles/PMC3531619/ /pubmed/22962028 http://dx.doi.org/10.1002/anie.201204308 Text en Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Communications
Chatterjee, Jayanta
Beullens, Monique
Sukackaite, Rasa
Qian, Junbin
Lesage, Bart
Hart, Darren J
Bollen, Mathieu
Köhn, Maja
Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**
title Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**
title_full Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**
title_fullStr Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**
title_full_unstemmed Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**
title_short Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**
title_sort development of a peptide that selectively activates protein phosphatase-1 in living cells**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531619/
https://www.ncbi.nlm.nih.gov/pubmed/22962028
http://dx.doi.org/10.1002/anie.201204308
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